Pattern, growth, and control
AD Lander - Cell, 2011 - cell.com
Systems biology seeks not only to discover the machinery of life but to understand how such
machinery is used for control, ie, for regulation that achieves or maintains a desired, useful …
machinery is used for control, ie, for regulation that achieves or maintains a desired, useful …
Using theoretical models to analyse neural development
A Van Ooyen - Nature Reviews Neuroscience, 2011 - nature.com
The development of the nervous system is an extremely complex and dynamic process.
Through the continuous interplay of genetic information and changing intra-and extracellular …
Through the continuous interplay of genetic information and changing intra-and extracellular …
[HTML][HTML] Circuit design features of a stable two-cell system
Cell communication within tissues is mediated by multiple paracrine signals including
growth factors, which control cell survival and proliferation. Cells and the growth factors they …
growth factors, which control cell survival and proliferation. Cells and the growth factors they …
Microenvironmental sensing by fibroblasts controls macrophage population size
Animal tissues comprise diverse cell types. However, the mechanisms controlling the
number of each cell type within tissue compartments remain poorly understood. Here, we …
number of each cell type within tissue compartments remain poorly understood. Here, we …
Cell lineages and the logic of proliferative control
It is widely accepted that the growth and regeneration of tissues and organs is tightly
controlled. Although experimental studies are beginning to reveal molecular mechanisms …
controlled. Although experimental studies are beginning to reveal molecular mechanisms …
What does the concept of the stem cell niche really mean today?
AD Lander, J Kimble, H Clevers, E Fuchs, D Montarras… - BMC biology, 2012 - Springer
© 2012 Lander et al; licensee BioMed Central Ltd. This is an Open Access article distributed
under the terms of the Creative Commons Attribution License (http://creativecommons …
under the terms of the Creative Commons Attribution License (http://creativecommons …
Mathematical modeling of leukemogenesis and cancer stem cell dynamics
T Stiehl, A Marciniak-Czochra - Mathematical Modelling of Natural …, 2012 - cambridge.org
The cancer stem cell hypothesis has evolved to one of the most important paradigms in
biomedical research. During recent years evidence has been accumulating for the existence …
biomedical research. During recent years evidence has been accumulating for the existence …
Clonal selection and therapy resistance in acute leukaemias: mathematical modelling explains different proliferation patterns at diagnosis and relapse
Recent experimental evidence suggests that acute myeloid leukaemias may originate from
multiple clones of malignant cells. Nevertheless, it is not known how the observed clones …
multiple clones of malignant cells. Nevertheless, it is not known how the observed clones …
The'stem cell'concept: is it holding us back?
AD Lander - Journal of biology, 2009 - Springer
Developmental biology, regenerative medicine and cancer biology are increasingly
occupied with the molecular characterization of stem cells. Yet recent work adds to a …
occupied with the molecular characterization of stem cells. Yet recent work adds to a …
Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1
J Wells, B Lee, AQ Cai, A Karapetyan, WJ Lee… - Journal of Biological …, 2009 - ASBMB
Ovol2 belongs to the Ovo family of evolutionarily conserved zinc finger transcription factors
that act downstream of key developmental signaling pathways including Wg/Wnt and …
that act downstream of key developmental signaling pathways including Wg/Wnt and …