Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic
drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit …

Programmed cell death (PCD) refers to the way in which cells die depending on specific
genes encoding signals or activities. Apoptosis, autophagy, and pyroptosis are all …

Cell death provides host defense and maintains homeostasis. Zα-containing molecules are
essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell …

Resistance to cell death is a hallmark of cancer. Immunotherapy, particularly immune
checkpoint blockade therapy, drives immune-mediated cell death and has greatly improved …

Abstract Interferon regulatory factor 1 (IRF1) regulates diverse biological functions, including
modulation of cellular responses involved in tumorigenesis. Genetic mutations and altered …

Programmed Cell Death (PCD) is considered to be a pathological form of cell death when
mediated by an intracellular program and it balances cell death with survival of normal cells …

Ion homeostasis is essential for cellular survival, and elevated concentrations of specific
ions are used to start distinct forms of programmed cell death. However, investigating the …

Gasdermin (GSDM)-mediated pyroptosis is functionally involved in multiple diseases, but
Gasdermin-B (GSDMB) exhibit cell death-dependent and independent activities in several …

The majority of current cancer immunotherapy strategies target and potentiate antitumor
adaptive immune responses. Unfortunately, the efficacy of these treatments has been limited …

Chimeric antigen receptor (CAR) T-cell therapy is a promising and rapidly expanding
therapeutic option for a wide range of human malignancies. Despite the ongoing progress of …