COVID-19 and multiorgan failure: A narrative review on potential mechanisms
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in
December 2019 form Wuhan, China leads to coronavirus disease 2019 (COVID-19) …
December 2019 form Wuhan, China leads to coronavirus disease 2019 (COVID-19) …
Neutrophils in acute inflammation: current concepts and translational implications
A Margraf, CA Lowell, A Zarbock - Blood, The Journal of the …, 2022 - ashpublications.org
Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to
sites of infection to combat invading pathogens while, at the same time, limiting host tissue …
sites of infection to combat invading pathogens while, at the same time, limiting host tissue …
[HTML][HTML] New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary
Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss
of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion …
of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion …
[HTML][HTML] COVID-19 and the liver: little cause for concern
The largest study on COVID-19 to date1 showed that the prevalence of elevated
aminotransferases and bilirubin in people faring worst was at least double that of others …
aminotransferases and bilirubin in people faring worst was at least double that of others …
In-hospital use of statins is associated with a reduced risk of mortality among individuals with COVID-19
Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have
been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk …
been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk …
Aging hallmarks and progression and age-related diseases: a landscape view of research advancement
Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …
Estimating risk of mechanical ventilation and in-hospital mortality among adult COVID-19 patients admitted to Mass General Brigham: The VICE and DICE scores
CJ Nicholson, L Wooster, HH Sigurslid, RH Li… - …, 2021 - thelancet.com
Background Risk stratification of COVID-19 patients upon hospital admission is key for their
successful treatment and efficient utilization of hospital resources. We sought to evaluate the …
successful treatment and efficient utilization of hospital resources. We sought to evaluate the …
Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adults
The COVID-19 pandemic serves as a potent reminder that older people are at very high risk
of adverse outcomes from infectious disease because of comorbidities associated with …
of adverse outcomes from infectious disease because of comorbidities associated with …
Statins use and COVID-19 outcomes in hospitalized patients
Background There is an urgent need for novel therapeutic strategies for reversing COVID-19-
related lung inflammation. Recent evidence has demonstrated that the cholesterol-lowering …
related lung inflammation. Recent evidence has demonstrated that the cholesterol-lowering …
Regulatory mechanisms of neutrophil migration from the circulation to the airspace
WC Lin, MB Fessler - Cellular and Molecular Life Sciences, 2021 - Springer
The neutrophil, a short-lived effector leukocyte of the innate immune system best known for
its proteases and other degradative cargo, has unique, reciprocal physiological interactions …
its proteases and other degradative cargo, has unique, reciprocal physiological interactions …