Proteases or proteolytic enzymes form one of the largest and more important groups of
enzymes. Proteases selectively catalyze the hydrolysis of peptide bonds and can be divided …

Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T
lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the …

There is compelling evidence that members of the caspase (interleukin-1β converting
enzyme/CED-3) family of cysteine proteases and the cytotoxic lymphocyte-derived serine …

R ECENT studies suggest that pro teases of the inter leukin 1-β-con-verting enzyme
(ICE)/ced-3 family are involved in initiating the active phase of apoptosis1–3. Here we …

Apoptosis is a morphologically distinct form of programmed cell death that plays a major role
during development, homeostasis, and in many diseases including cancer, acquired …

Abstract Structure‐based mutational analysis of serine protease specificity has produced a
large database of information useful in addressing biological function and in establishing a …

We have generated H-2b mice with a homozygoua null mutation in the granzyme (gzm) B
gene. Gzm B is a neutral serine protease with Aspase activity that is found only in …

The suppressive capacity of naturally occurring mouse CD4+ CD25+ T cells on T-cell
activation has been well documented. The present study is focused on the interaction of …

Murine L929 fibrosarcoma cells were transfected with the human Fas (APO-1/CD95)
receptor, and the role of various caspases in Fas-mediated cell death was assessed …

Cytotoxic T lymphocytes, differentiated CD8+ T cells, use multiple mechanisms to mediate
their function, including release of granules containing perforin and granzymes at target …