Glucagon-Like Peptides | Endocrine Reviews | Oxford Academic Skip to Main Content
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The pancreas is an organ containing two distinct populations of cells, the exocrine cells that
secrete enzymes into the digestive tract, and the endocrine cells that secrete hormones into …

THE mammalian pancreas is a mixed exocrine and endocrine gland that, in most species,
arises from ventral and dorsal buds which subsequently merge to form the pancreas. In both …

Candidate transcription factors involved in pancreatic endocrine development have been
isolated using insulin gene regulation as a paradigm. The cell-type restricted basic helix …

Genes encoding homeodomain-containing proteins potentially involved in endocrine
pancreas development were isolated by combined in silico and nested-PCR approaches …

Glucagon, a hormone secreted from the α-cells of the endocrine pancreas, is critical for
blood glucose homeostasis. It is the major counterpart to insulin and is released during …

The peptide hormone urocortin3 (Ucn3) is abundantly expressed by mature beta cells, yet its
physiological role is unknown. Here we demonstrate that Ucn3 is stored and co-released …

We describe the cloning of insulin promoter factor 1 (IPF1), a homeodomain protein which in
the adult mouse pancreas is selectively expressed in the beta‐cells and which binds to and …

To analyze cell lineage in the pancreatic islets, we have irreversibly tagged all the progeny
of cells through the activity of Cre recombinase. Adult glucagon (α) and insulin (β) cells are …

Pancreatic development represents a fascinating process in which two morphologically
distinct tissue types must derive from one simple epithelium. These two tissue types …