Mycobacterium tuberculosis (Mtb) is the causative agent of human tuberculosis (TB) which
primarily infects the macrophages. Nearly a quarter of the world's population is infected …

In the last ten years, it has become increasingly clear that tumor-infiltrating myeloid cells
drive not just carcinogenesis via cancer-related inflammatory processes, but also tumor …

The immunosuppressive tumor microenvironment (TME) represents a major barrier for
effective immunotherapy. Tumor-associated macrophages (TAMs) are highly heterogeneous …

Tumor-associated macrophages (TAM) have attracted attention as they can modulate key
cancer-related activities, yet TAM represent a heterogenous group of cells that remain …

Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune
checkpoint blockade (ICB) is rare. SCLC also exhibits cellular plasticity, which could …

Immunotherapies targeting the PD-1/PD-L1 axis are now a mainstay in the clinical
management of multiple cancer types, however, many tumors still fail to respond. CCL2 is …

Eicosanoids represent a family of active biolipids derived from arachidonic acid primarily
through the action of cytosolic phospholipase A2-α. Three major downstream pathways …

The transcription factor FOSL1 plays an important role in cell differentiation and
tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages …

Renewed interest in immune cell metabolism has led to the emergence of a research field
aimed at studying the importance of metabolic processes for an effective immune response …

In order to adapt to the reduced availability of nutrients and oxygen in the tumor
microenvironment and the increased requirements of energy and building blocks necessary …