Innate sensing of malaria parasites

RT Gazzinelli, P Kalantari, KA Fitzgerald… - Nature Reviews …, 2014 - nature.com
Innate immune receptors have a key role in immune surveillance by sensing
microorganisms and initiating protective immune responses. However, the innate immune …

Innate immune mechanisms to protect against infection at the human decidual-placental interface

R Hoo, A Nakimuli, R Vento-Tormo - Frontiers in immunology, 2020 - frontiersin.org
During pregnancy, the placenta forms the anatomical barrier between the mother and
developing fetus. Infectious agents can potentially breach the placental barrier resulting in …

Congenital transmission of apicomplexan parasites: a review

M Rojas-Pirela, L Medina, MV Rojas… - Frontiers in …, 2021 - frontiersin.org
Apicomplexans are a group of pathogenic protists that cause various diseases in humans
and animals that cause economic losses worldwide. These unicellular eukaryotes are …

Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes

AS Reis, R Barboza, O Murillo, A Barateiro… - Science …, 2020 - science.org
Placental malaria (PM) is associated with severe inflammation leading to abortion, preterm
delivery, and intrauterine growth restriction. Innate immunity responses play critical roles, but …

TLR4-mediated placental pathology and pregnancy outcome in experimental malaria

R Barboza, FA Lima, AS Reis, OJ Murillo… - Scientific Reports, 2017 - nature.com
Malaria-associate pregnancy has a significant impact on infant morbidity and mortality. The
detrimental effects of malaria infection during pregnancy have been shown to correlate with …

Interferons and interferon regulatory factors in malaria

SY Gun, C Claser, KSW Tan… - Mediators of inflammation, 2014 - Wiley Online Library
Malaria is one of the most serious infectious diseases in humans and responsible for
approximately 500 million clinical cases and 500 thousand deaths annually. Acquired …

Integrated Proteomics Reveals Apoptosis-related Mechanisms Associated with Placental Malaria*[S]

R Kawahara, L Rosa-Fernandes, AF Dos Santos… - Molecular & Cellular …, 2019 - ASBMB
Malaria in pregnancy is a public health concern in malaria-endemic areas. Accumulation of
maternal immune cells in the placenta and increased levels of inflammatory cytokines …

Immunohistopathological changes in the placenta of malaria-infected women in unstable transmission setting of Aligarh

A Naheda, S Aqeel, K Khan, W Khan, T Khan - Placenta, 2022 - Elsevier
Introduction Pregnant women are more susceptible to malaria due to a combination of
physiological and immunological changes. The infection may even affect the growth and …

Dynamics of Plasmodium berghei NK-65 parasitaemia and CD3+CD4+CD25+Fox-p3+ T-regulatory cells in experimentally induced malaria during early, mid, and …

PL Manhas, M Sharma, A Mewara… - Indian Journal of …, 2023 - Springer
Introduction Malaria in pregnancy causes a dual brunt on the mother as well as the foetus.
Upregulation of T-regulatory cells (Tregs) during pregnancy allows tolerance towards the …

IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites

M Niikura, SI Inoue, S Mineo, H Asahi, F Kobayashi - PLoS One, 2017 - journals.plos.org
Complicated/severe cases of placental pathology due to Plasmodium falciparum and P.
vivax, especially adverse pregnancy outcomes during P. vivax infection, have been …