The intersection between cysteine proteases, Ca2+ signalling and cancer cell apoptosis
T Hua, M Robitaille, SJ Roberts-Thomson… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Apoptosis is a highly complex and regulated cell death pathway that safeguards the
physiological balance between life and death. Over the past decade, the role of Ca 2+ …
physiological balance between life and death. Over the past decade, the role of Ca 2+ …
[HTML][HTML] The relevance of organelle interactions in cellular senescence
J Huang, P Meng, C Wang, Y Zhang, L Zhou - Theranostics, 2022 - ncbi.nlm.nih.gov
Organelles are tiny structures with specific functions in eukaryotic cells. Since they are
covered with membranes, different organelles can perform biological processes that are …
covered with membranes, different organelles can perform biological processes that are …
[HTML][HTML] Blunting ROS/TRPML1 pathway protects AFB1-induced porcine intestinal epithelial cells apoptosis by restoring impaired autophagic flux
X Cheng, J Liang, D Wu, X Guo, H Cao, C Zhang… - Ecotoxicology and …, 2023 - Elsevier
Abstract Aflatoxin B1 (AFB1) is a stable mycotoxin that contaminates animal feed on a large
scale and causes severe damage to intestinal cells, induces inflammation and stimulates …
scale and causes severe damage to intestinal cells, induces inflammation and stimulates …
TRPML1 ameliorates seizures-related neuronal injury by regulating autophagy and lysosomal biogenesis via Ca2+/TFEB signaling pathway
T Peng, Y Xie, S Zhao, X Wang, W Zhang, Y Xie… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Alterations in autophagy have been observed in epilepsy, although their exact
etiopathogenesis remains elusive. Transient Receptor Potential Mucolipin Protein 1 …
etiopathogenesis remains elusive. Transient Receptor Potential Mucolipin Protein 1 …
Highly Potent and Selective Dopamine D4 Receptor Antagonists Potentially Useful for the Treatment of Glioblastoma
To better understand the role of dopamine D4 receptor (D4R) in glioblastoma (GBM), in the
present paper, new ligands endowed with high affinity and selectivity for D4R were …
present paper, new ligands endowed with high affinity and selectivity for D4R were …
Relevance of lysosomal Ca2+ signalling machinery in cancer
S Barbonari, A D'Amore, F Palombi, P De Cesaris… - Cell Calcium, 2022 - Elsevier
In comparison with normal cells, cancer cells are equipped with a higher number of
lysosomes, involved in degradative and non-degradative roles. In particular, the lysosome is …
lysosomes, involved in degradative and non-degradative roles. In particular, the lysosome is …
Coexpression of TRPML1 and TRPML2 mucolipin channels affects the survival of glioblastoma patients
Among brain cancers, glioblastoma (GBM) is the most malignant glioma with an extremely
poor prognosis. It is characterized by high cell heterogeneity, which can be linked to its high …
poor prognosis. It is characterized by high cell heterogeneity, which can be linked to its high …
TPC2 targeting evolution: Leveraging therapeutic opportunities for cancer
AF Alharbi, J Parrington - Cell Chemical Biology, 2021 - cell.com
Growing evidence implicates a vital role for TPC2/Ca 2+ signaling in pathophysiological
processes attributed to cancer, raising questions regarding the utility of TPC2 as a cancer …
processes attributed to cancer, raising questions regarding the utility of TPC2 as a cancer …
Functional in vitro assessment of VEGFA/NOTCH2 signaling pathway and pRB proteasomal degradation and the clinical relevance of mucolipin TRPML2 …
Glioblastoma (GBM) is the most malignant glioma with an extremely poor prognosis. It is
characterized by high vascularization and its growth depends on the formation of new blood …
characterized by high vascularization and its growth depends on the formation of new blood …
Design, Synthesis and Biological Evaluation of Potent and Selective Dopamine or Sigma Receptor Ligands Sharing a Common Pharmacophore
P Pavletic - 2023 - pubblicazioni.unicam.it
UNIVERSITÀ DEGLI STUDI DI CAMERINO Page 1 UNIVERSITÀ DEGLI STUDI DI CAMERINO
SCHOOL OF ADVANCED STUDIES Doctoral course in: Chemical and Pharmaceutical Sciences …
SCHOOL OF ADVANCED STUDIES Doctoral course in: Chemical and Pharmaceutical Sciences …