Meta-hallmarks of aging and cancer
Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
Ageing and rejuvenation of tissue stem cells and their niches
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
Control of satellite cell function in muscle regeneration and its disruption in ageing
P Sousa-Victor, L García-Prat… - … Reviews Molecular Cell …, 2022 - nature.com
Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice
Partial reprogramming by expression of reprogramming factors (Oct4, Sox2, Klf4 and c-Myc)
for short periods of time restores a youthful epigenetic signature to aging cells and extends …
for short periods of time restores a youthful epigenetic signature to aging cells and extends …
In vivo partial cellular reprogramming enhances liver plasticity and regeneration
T Hishida, M Yamamoto, Y Hishida-Nozaki, C Shao… - Cell reports, 2022 - cell.com
Mammals have limited regenerative capacity, whereas some vertebrates, like fish and
salamanders, are able to regenerate their organs efficiently. The regeneration in these …
salamanders, are able to regenerate their organs efficiently. The regeneration in these …
In vivo reprogramming leads to premature death linked to hepatic and intestinal failure
The induction of cellular reprogramming via expression of the transcription factors Oct4,
Sox2, Klf4 and c‐Myc (OSKM) can drive dedifferentiation of somatic cells and ameliorate …
Sox2, Klf4 and c‐Myc (OSKM) can drive dedifferentiation of somatic cells and ameliorate …
A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan
Q Alle, E Le Borgne, P Bensadoun, C Lemey… - Aging …, 2022 - Wiley Online Library
Recent advances in cell reprogramming showed that OSKM induction is able to improve cell
physiology in vitro and in vivo. Here, we show that a single short reprogramming induction is …
physiology in vitro and in vivo. Here, we show that a single short reprogramming induction is …
The emergence of the stem cell niche
Stem cell niches are composed of dynamic microenvironments that support stem cells over a
lifetime. The emerging niche is distinct from the adult because its main role is to support the …
lifetime. The emerging niche is distinct from the adult because its main role is to support the …
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
A Huyghe, A Trajkova, F Lavial - Trends in cell biology, 2024 - cell.com
The multistep process of in vivo reprogramming, mediated by the transcription factors (TFs)
Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of …
Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of …
Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging
Nuclear deformation, a hallmark frequently observed in senescent cells, is presumed to be
associated with the erosion of chromatin organization at the nuclear periphery. However …
associated with the erosion of chromatin organization at the nuclear periphery. However …