A model checking approach to discrete bifurcation analysis

N Beneš, L Brim, M Demko, S Pastva… - FM 2016: Formal Methods …, 2016 - Springer
Bifurcation analysis is a central task of the analysis of parameterised high-dimensional
dynamical systems that undergo transitions as parameters are changed. The classical …

Computational Modelling of Metabolic Burden and Substrate Toxicity in Escherichia coli Carrying a Synthetic Metabolic Pathway

M Demko, L Chrást, P Dvořák, J Damborský… - Microorganisms, 2019 - mdpi.com
In our previous work, we designed and implemented a synthetic metabolic pathway for 1, 2,
3-trichloropropane (TCP) biodegradation in Escherichia coli. Significant effects of metabolic …

Pithya: a parallel tool for parameter synthesis of piecewise multi-affine dynamical systems

N Beneš, L Brim, M Demko, S Pastva… - … Aided Verification: 29th …, 2017 - Springer
We present a novel tool for parameter synthesis of piecewise multi-affine dynamical systems
from specifications expressed in a hybrid branching-time temporal logic. The tool is based …

[PDF][PDF] Symbolic Synthesis of Fault-Tolerance Ratios in Parameterised Multi-Agent Systems.

P Kouvaros, A Lomuscio, E Pirovano - IJCAI, 2018 - ijcai.org
We study the problem of determining the robustness of a multi-agent system of unbounded
size against specifications expressed in a temporalepistemic logic. We introduce a …

[HTML][HTML] Constrained Kripke structure for identifying parameters of biological models

JP Comet, H Collavizza, L Gibart - Theoretical Computer Science, 2024 - Elsevier
When modelling a complex biological system, the bottleneck of the process is the
determination of parameter values that lead to model dynamics that are compatible with …

High-performance symbolic parameter synthesis of biological models: a case study

M Demko, N Beneš, L Brim, S Pastva… - … Computational Methods in …, 2016 - Springer
Complex behaviour arising in biological systems is described by highly parameterised
dynamical models. Most of the parameters are mutually dependent and therefore it is hard …

[HTML][HTML] Parallel parameter synthesis algorithm for hybrid CTL

N Beneš, L Brim, S Pastva, D Šafránek - Science of Computer …, 2020 - Elsevier
Parametrised models of dynamical systems arise in various areas of science. In this work,
we focus on models described as parametrised Kripke structures with properties formulated …

Model checking approach to the analysis of biological systems

N Beneš, L Brim, S Pastva, D Šafránek - Automated Reasoning for …, 2019 - Springer
Formal verification techniques together with other computer science formal methods have
been recently tailored for applications to biological and biomedical systems. In contrast to …

Occupation measure methods for modelling and analysis of biological hybrid systems

A Rocca, M Forets, V Magron, E Fanchon, T Dang - IFAC-PapersOnLine, 2018 - Elsevier
Mechanistic models in biology often involve numerous parameters about which we do not
have direct experimental information. The traditional approach is to fit these parameters …

[图书][B] Computer aided cerification

R Majumdar, V Kuncak - 2017 - Springer
It has been our privilege to serve as the program chairs for CAV 2017, the 29th International
Conference on Computer-Aided Verification. CAV 2017 was held in beautiful Heidelberg …