Advances in the chemical synthesis of C-pyranosides/furanosides are summarized, covering
the literature from 2000 to 2016. The majority of the methods take advantage of the …

Abstract Uridine diphosphate-3-O-(hydroxymyristoyl)-N-acetylglucosamine deacetylase
(LpxC) is a metalloenzyme with zinc ions as cofactors and is a key enzyme in the essential …

In order to increase the application of natural bioresources in drug discovery and
development, a study on N-acetyl-glucosamine (GlcNAc) derivatives of chitin as green …

In order to develop novel inhibitors of the bacterial deacetylase LpxC bearing a substituent
to target the UDP binding site of the enzyme, a series of aldotetronic acid-based hydroxamic …

The bacterial deacetylase LpxC is a promising target for the development of novel antibiotics
being selectively active against Gram-negative bacteria. In chiral pool syntheses starting …

Human deaths caused by Gram-negative bacteria keep rising due to the multidrug
resistance (MDR) phenomenon. Therefore, it is a priority to develop novel antibiotics with …

The exploration of hybridization emerges as a potent tool in advancing drug discovery
research, with a significant emphasis on carbohydrate-containing hybrid scaffolds. Evidence …

Inhibitors of the bacterial deacetylase LpxC are a promising class of novel antibiotics, being
selectively active against Gram‐negative bacteria. To improve the biological activity of …

The bacterial deacetylase LpxC is a promising target for the development of antibiotics
selectively combating Gram-negative bacteria. To improve the biological activity of the …

LpxC inhibitors represent a promising class of novel antibiotics selectively combating Gram-
negative bacteria. In chiral pool syntheses starting from D-and L-xylose, a series of four 2r …