Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements

V Aggarwal, HS Tuli, A Varol, F Thakral, MB Yerer… - Biomolecules, 2019 - mdpi.com
Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …

Resistance to molecularly targeted therapies in melanoma

M Patel, A Eckburg, S Gantiwala, Z Hart, J Dein, K Lam… - Cancers, 2021 - mdpi.com
Simple Summary Metastatic melanoma has poor survival rates in comparison to other types
of skin cancer. Traditional therapies are not very effective in treating advanced melanoma …

pH‐Sensitive Molecular‐Switch‐Containing Polymer Nanoparticle for Breast Cancer Therapy with Ferritinophagy‐Cascade Ferroptosis and Tumor Immune Activation

T Zuo, T Fang, J Zhang, J Yang, R Xu… - Advanced …, 2021 - Wiley Online Library
Ferritin internalized into tumor cells is degraded and releases iron ions via ferritinophagy.
Iron ions participate in Fenton reaction to produce reactive oxygen species for lipid …

Investigation on graphdiyne nanosheet in adsorption of sorafenib and regorafenib drugs: a DFT approach

U Srimathi, V Nagarajan, R Chandiramouli - Journal of Molecular Liquids, 2019 - Elsevier
We investigated the electronic characteristics of graphdiyne nanosheet (Gdn-NS) using first-
principles calculation. The Gdn-NS possesses the energy gap value of 0.52 eV. Also, the …

COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice

RM Gonçalves, M Delgobo, JP Agnes, RN das Neves… - Cancer Letters, 2021 - Elsevier
Obesity is a major risk factor for breast cancer, especially in post-menopausal women. In the
breast tissue of obese women, cyclooxygenase-2 (COX-2)-dependent prostaglandin E2 …

A Bi 2 S 3-embedded gellan gum hydrogel for localized tumor photothermal/antiangiogenic therapy

Y Wu, Y Liang, Y Liu, Y Hao, N Tao, J Li… - Journal of Materials …, 2021 - pubs.rsc.org
An injectable gellan gum-based nanocomposite hydrogel (Bi2S3@ GG) was designed for X-
ray computed tomography (CT) imaging and photothermal/antiangiogenic therapy. The …

[HTML][HTML] Inhibitory effects of Paris saponin I, II, Ⅵ and Ⅶ on HUVEC cells through regulation of VEGFR2, PI3K/AKT/mTOR, Src/eNOS, PLCγ/ERK/MERK, and JAK2 …

W Wang, Y Liu, L You, M Sun, C Qu, XX Dong… - Biomedicine & …, 2020 - Elsevier
Rhizoma Paris is a popular Chinese medicine in clinics. It contains four main saponins
which are its major bioactive compounds. These saponins are Paris saponin I, II, VI and VII …

Vascular endothelial growth factor receptors [VEGFR] as target in breast cancer treatment: current status in preclinical and clinical studies and future directions

M Malekan, MA Ebrahimzadeh - Current Topics in Medicinal …, 2022 - ingentaconnect.com
Breast cancer [BC] is one of the most common cancers among women, one of the leading
causes of a considerable number of cancer-related death globally. Among all procedures …

TNF‑α promotes the malignant transformation of intestinal stem cells through the NF‑κB and Wnt/β‑catenin signaling pathways

X Zhao, L Ma, L Dai, D Zuo, X Li… - Oncology …, 2020 - spandidos-publications.com
Cancer stem cells are responsible for tumorigenesis, progression, recurrence and
metastasis. Intestinal stem cells (ISCs) are regarded as the origin of intestinal neoplasia …

Berberine inhibits human melanoma A375. S2 cell migration and invasion via affecting the FAK, uPA, and NF-κB signaling pathways and inhibits PLX4032 resistant …

JF Liu, KC Lai, SF Peng, P Maraming, YP Huang… - Molecules, 2018 - mdpi.com
Many studies have demonstrated that berberine inhibited the cell migration and invasion in
human cancer cell lines. However, the exact molecular mechanism of berberine inhibiting …