Biosensing with dnazymes

EM McConnell, I Cozma, Q Mou, JD Brennan… - Chemical Society …, 2021 - pubs.rsc.org
This article provides a comprehensive review of biosensing with DNAzymes, providing an
overview of different sensing applications while highlighting major progress and seminal …

Therapeutic DNAzymes: from structure design to clinical applications

J Yan, M Ran, X Shen, H Zhang - Advanced Materials, 2023 - Wiley Online Library
Therapeutic DNAzymes have unceasingly intrigued the scientific community owing to their
prosperous gene regulation capability. The efficacy of DNAzymes against many types of …

[HTML][HTML] From cascaded catalytic nucleic acids to enzyme–DNA nanostructures: controlling reactivity, sensing, logic operations, and assembly of complex structures

F Wang, CH Lu, I Willner - Chemical reviews, 2014 - ACS Publications
DNA is one of the most fascinating biopolymers. Besides its central role as carrier of genetic
information and translation of the genetic code into proteins, DNA holds great promise as a …

Isothermal amplified detection of DNA and RNA

L Yan, J Zhou, Y Zheng, AS Gamson… - Molecular …, 2014 - pubs.rsc.org
This review highlights various methods that can be used for a sensitive detection of nucleic
acids without using thermal cycling procedures, as is done in PCR or LCR. Topics included …

DNA-mediated homogeneous binding assays for nucleic acids and proteins

H Zhang, F Li, B Dever, XF Li, XC Le - Chemical reviews, 2013 - ACS Publications
The detection of nucleic acids and proteins is fundamental for studying their functions and
for the development of molecular diagnostics. These molecules carry out most biological …

[HTML][HTML] Theranostic dnazymes

W Zhou, J Ding, J Liu - Theranostics, 2017 - ncbi.nlm.nih.gov
DNAzymes are catalytically active DNA molecules that are obtained via in vitro selection.
RNA-cleaving DNAzymes have attracted significant attention for both therapeutic and …

Mimicking Horseradish Peroxidase and NADH Peroxidase by Heterogeneous Cu2+-Modified Graphene Oxide Nanoparticles

S Wang, R Cazelles, WC Liao… - Nano …, 2017 - ACS Publications
Cu2+-ion-modified graphene oxide nanoparticles, Cu2+-GO NPs, act as a heterogeneous
catalyst mimicking functions of horseradish peroxidase, HRP, and of NADH peroxidase. The …

DNA computing circuits using libraries of DNAzyme subunits

J Elbaz, O Lioubashevski, F Wang, F Remacle… - Nature …, 2010 - nature.com
Biological systems that are capable of performing computational operations,, could be of use
in bioengineering and nanomedicine,, and DNA and other biomolecules have already been …

Amplified analysis of DNA by the autonomous assembly of polymers consisting of DNAzyme wires

F Wang, J Elbaz, R Orbach, N Magen… - Journal of the American …, 2011 - ACS Publications
A systematic study of the amplified optical detection of DNA by Mg2+-dependent DNAzyme
subunits is described. The use of two DNAzyme subunits and the respective …

Amplified detection of DNA through the enzyme-free autonomous assembly of hemin/G-quadruplex DNAzyme nanowires

S Shimron, F Wang, R Orbach, I Willner - Analytical chemistry, 2012 - ACS Publications
An enzyme-free amplified detection platform is described using the horseradish peroxidase
(HRP)-mimicking DNAzyme as an amplifying label. Two hairpin structures that include three …