A researcher's guide to preclinical mouse NASH models

S Gallage, JEB Avila, P Ramadori, E Focaccia… - Nature …, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) and its inflammatory form, non-alcoholic
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …

Non-alcoholic steatohepatitis: a review of its mechanism, models and medical treatments

C Peng, AG Stewart, OL Woodman… - Frontiers in …, 2020 - frontiersin.org
Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease
(NAFLD). Currently, around 25% of the population is estimated to have NAFLD, and 25% of …

Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1

BS Gosis, S Wada, C Thorsheim, K Li, S Jung… - Science, 2022 - science.org
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain
without effective therapies. The mechanistic target of rapamycin complex 1 (mTORC1) …

Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)

S Wang, SL Friedman - Science translational medicine, 2023 - science.org
Metabolic dysfunction–associated steatohepatitis (MASH) is a severe form of liver disease
that poses a global health threat because of its potential to progress to advanced fibrosis …

Diet-induced models of non-alcoholic fatty liver disease: food for thought on sugar, fat, and cholesterol

JM Eng, JL Estall - Cells, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) affects approximately 1 in 4 people worldwide and
is a major burden to health care systems. A major concern in NAFLD research is lack of …

Genetic and diet-induced animal models for non-alcoholic fatty liver disease (NAFLD) research

CM Flessa, N Nasiri-Ansari, I Kyrou, BM Leca… - International Journal of …, 2022 - mdpi.com
A rapidly increasing incidence of non-alcoholic fatty liver disease (NAFLD) is noted
worldwide due to the adoption of western-type lifestyles and eating habits. This makes the …

[HTML][HTML] PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease

ME Moreno-Fernandez, DA Giles, JR Oates, CC Chan… - Cell metabolism, 2021 - cell.com
Emerging evidence suggests a key contribution to non-alcoholic fatty liver disease (NAFLD)
pathogenesis by Th17 cells. The pathogenic characteristics and mechanisms of hepatic …

Ursodeoxycholic acid treatment restores gut microbiota and alleviates liver inflammation in non-alcoholic steatohepatitic mouse model

H Li, Q Wang, P Chen, C Zhou, X Zhang… - Frontiers in …, 2021 - frontiersin.org
Gut microbiota dysbiosis plays an important role in the progression of non-alcoholic fatty
liver disease (NAFLD), and no approved drugs are available for NAFLD treatment. In this …

NAFLD preclinical models: more than a handful, less of a concern?

Y Oligschlaeger, R Shiri-Sverdlov - Biomedicines, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver diseases ranging from
simple steatosis to non-alcoholic steatohepatitis, fibrosis, cirrhosis, and/or hepatocellular …

Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

HH Hansen, HM Ægidius, D Oró, SS Evers… - BMC …, 2020 - Springer
Background Animal models of non-alcoholic steatohepatitis (NASH) are important tools in
preclinical research and drug discovery. Gubra-Amylin NASH (GAN) diet-induced obese …