Anti-ro/ssa and la/ssb antibodies

F Franceschini, I Cavazzana - Autoimmunity, 2005 - Taylor & Francis
The Ro/La system is considered as an heterogeneous antigenic complex, constituted by
three different proteins (52 kDa Ro, 60 kDa Ro and La) and four small RNAs particles. Anti …

Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody‐associated congenital heart block: retrospective review of the research …

S Saleeb, J Copel, D Friedman… - Arthritis & Rheumatism …, 1999 - Wiley Online Library
Objective To compare intervention with fluorinated glucocorticoids to the natural history of
untreated congenital heart block (CHB) with respect to conduction abnormalities, associated …

Pregnancy outcomes in patients with autoimmune diseases and anti-Ro/SSA antibodies

A Brucato, R Cimaz, R Caporali, V Ramoni… - Clinical reviews in allergy …, 2011 - Springer
Anti-Ro/SSA antibodies are associated with neonatal lupus (congenital heart block (CHB),
neonatal transient skin rash, hematological and hepatic abnormalities), but do not negatively …

Clinical and pathological roles of Ro/SSA autoantibody system

R Yoshimi, A Ueda, K Ozato… - Journal of Immunology …, 2012 - Wiley Online Library
Anti‐Ro/SSA antibodies are among the most frequently detected autoantibodies against
extractable nuclear antigens and have been associated with systemic lupus erythematosus …

Signs of first‐degree heart block occur in one‐third of fetuses of pregnant women with anti–SSA/Ro 52‐kd antibodies

SE Sonesson, S Salomonsson… - … : Official Journal of …, 2004 - Wiley Online Library
Objective To prospectively investigate the development of fetal heart block in anti–SSA/Ro
52‐kd–positive women, and to evaluate the usefulness of serial Doppler echocardiography …

Autoimmune channelopathies as a novel mechanism in cardiac arrhythmias

PE Lazzerini, PL Capecchi, F Laghi-Pasini… - Nature Reviews …, 2017 - nature.com
Cardiac arrhythmias confer a considerable burden of morbidity and mortality in
industrialized countries. Although coronary artery disease and heart failure are the prevalent …

Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies

AD Askanase, DM Friedman, J Copel, MR Dische… - Lupus, 2002 - journals.sagepub.com
The classic cardiac manifestation of neonatal lupus is congenitalheart block, attributed to
antibodymediated inflammation and subsequent fibrosis of the atrioventricular (AV) node. In …

[HTML][HTML] Neonatal lupus erythematosus

LA Lee - Journal of investigative dermatology, 1993 - Elsevier
Neonatal lupus erythematosus (NLE) is an autoimmune disease whose major findings are
subacute cutaneous lupus erythematosus (SCLE) skin lesions and congenital heart block …

Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside

JP Buyon, RM Clancy, DM Friedman - Nature Reviews Rheumatology, 2009 - nature.com
One of the strongest clinical associations with autoantibodies against components of the
SSA/Ro–SSB/La ribonucleoprotein complex is the development of congenital heart block in …

Congenital heart block: evidence for a pathogenic role of maternal autoantibodies

A Ambrosi, M Wahren-Herlenius - Arthritis research & therapy, 2012 - Springer
During pregnancy in autoimmune conditions, maternal autoantibodies are transported
across the placenta and may affect the developing fetus. Congenital heart block (CHB) is …