Pathogenic mutations in mitochondrial DNA (mtDNA) compromise cellular metabolism,
contributing to cellular heterogeneity and disease. Diverse mutations are associated with …

Summary Background Mitochondrial DNA (mtDNA) encodes 37 genes necessary for
synthesizing 13 essential subunits of the oxidative phosphorylation system. mtDNA …

Mitochondria have been linked to the etiology of schizophrenia (SZ). However, studies of
mitochondria in SZ might be confounded by the effects of pharmacological treatment with …

Mitochondrial dysfunction is a neurobiological phenomenon implicated in the
pathophysiology of schizophrenia and bipolar disorder that can synergistically affect …

Background Acquired human mitochondrial genome (mtDNA) deletions are symptoms and
drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and …

Deletions and duplications in mitochondrial DNA (mtDNA) cause mitochondrial disease and
accumulate in conditions such as cancer and age-related disorders, but validated high …

ABSTRACT Introduction Primary mitochondrial diseases (PMDs) comprise a large and
heterogeneous group of genetic diseases that result from pathogenic variants in either …

The aim of this study was to investigate the possible interaction of mitochondrial dysfunction
and inflammatory cytokines in the risk of anxiety and depression. We utilized the UK Biobank …

The kinetics of folding is crucial for the function of many regulatory RNAs including RNA G-
quadruplexes (rG4s). Here, we characterize the folding pathways of a G-quadruplex from the …

Common mitochondrial DNA (mtDNA) deletions are large structural variants in the
mitochondrial genome that accumulate in metabolically active tissues with age and have …