Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain …

The latest advances in next‐generation sequencing studies and transcriptomic profiling over
the past decade have highlighted a surprising frequency of genes regulated by RNA …

Various disciplines cooperate to find novel approaches to cure impaired body functions by
repairing, replacing, or regenerating cells, tissues, or organs. The possibility that a stable …

Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell
subsets, which protects from immunopathogenesis, but also hampers the development of …

Patients with type 2 diabetes (T2D) are more susceptible to severe respiratory viral
infections, but the underlying mechanisms remain elusive. Here, we show that patients with …

In the era of personalized medicine, insights into the molecular mechanisms that
differentially contribute to disease phenotypes, such as asthma phenotypes including …

Adoptive transfer of T cells expressing chimeric antigen receptors (CAR-T) effectively treats
refractory hematologic malignancies in a subset of patients but can be limited by poor T-cell …

Skeletal muscle has a robust, inherent ability to regenerate in response to injury from acute
to chronic. In severe trauma, however, complete regeneration is not possible, resulting in a …

Alternative RNA splicing, a ubiquitous mechanism of gene regulation in eukaryotes,
expands genome coding capacity and proteomic diversity. It has essential roles in all …

Abstract Purpose Chromosome 22q11. 2 deletion syndrome is a common inborn error of
immunity. The early consequences of thymic hypoplasia are low T cell numbers. Later in life …