The cell cycle is a series of events by which cellular components are accurately segregated
into daughter cells, principally controlled by the oscillating activities of cyclin-dependent …

For decades after the discovery that a contractile ring made of actin filaments and myosin II
produces the force to constrict the cleavage furrow of animal cells, the complexity of …

The position of Chlamydomonas within the eukaryotic phylogeny makes it a unique model in
at least two important ways: as a representative of the critically important, early‐diverging …

Cell-cycle control of transcription seems to be universal, but little is known about its global
conservation and biological significance. We report on the genome-wide transcriptional …

Animals and fungi assemble a contractile ring of actin filaments and the motor protein
myosin to separate into individual daughter cells during cytokinesis. We used fluorescence …

The terminal step in cytokinesis, called abscission, requires resolution of the membrane
connection between two prospective daughter cells. Our previous studies demonstrated that …

Microscopy of fluorescent fusion proteins and genetic dependencies show that fission yeast
assemble and constrict a cytokinetic contractile ring in a precisely timed, sequential order …

Stable intercellular bridges are a conserved feature of gametogenesis in multicellular
animals observed more than 100 years ago, but their function was unknown. Many of the …

In creating the mitotic spindle and the contractile ring, natural selection has engineered
fascinating precision machines whose movements depend upon forces generated by …

During anaphase, spindle elongation pulls sister chromatids apart until each pair is fully
separated. In turn, cytokinesis cleaves the cell between the separated chromosomes. What …