Cancer has remained to be one of the major challenges in medicine and regarded as the
second leading cause of death worldwide. Different types of cancer may resist anti-cancer …

Arsenic-induced carcinogenesis is a worldwide health problem. Identifying the molecular
mechanisms responsible for the induction of arsenic-induced cancers is important for …

Mutations that activate oncogenes and deactivate tumor suppressor genes are widely
recognized as significant contributors to cancer development. We investigated relationships …

Our previous study showed that sodium arsenite (200 mg/L) affected the nervous system
and induced motor neuron development via the Sonic hedgehog pathway in zebrafish …

Purpose Cancer registries offer an avenue to identify cancer clusters across large
populations and efficiently examine potential environmental harms affecting cancer. The role …

Long-term exposure to arsenic has been linked to a variety of cancers, among which skin
cancer is the most prevalent form. However, the mechanism underlying arsenic …

Disrupted cell cycle progression underlies the molecular pathogenesis of multiple diseases.
Chronic exposure to inorganic arsenic (iAs) is a global health issue leading to multi-organ …

Dysregulated miRNA expression contributes to development of arsenic-induced cutaneous
squamous cell carcinoma (cSCC). hsa-miR-186 (miR-186) is overexpressed in arsenical …

Biological processes are inherently stochastic, ie, are partially driven by hard to predict
random probabilistic processes. Carcinogenesis is driven both by stochastic and …

Abstract Purpose of Review Chronic inorganic arsenic (iAs) exposure affects over 220
million people throughout the world. Given that iAs is ubiquitous in the environment, it is …