Improving outcomes of first‐episode psychosis: an overview

P Fusar‐Poli, PD McGorry, JM Kane - World psychiatry, 2017 - Wiley Online Library
Outcomes of psychotic disorders are associated with high personal, familiar, societal and
clinical burden. There is thus an urgent clinical and societal need for improving those …

What causes the onset of psychosis in individuals at clinical high risk? A meta-analysis of risk and protective factors

D Oliver, TJ Reilly, O Baccaredda Boy… - Schizophrenia …, 2020 - academic.oup.com
Twenty percent of individuals at clinical high risk for psychosis (CHR-P) develop the disorder
within 2 years. Extensive research has explored the factors that differentiate those who …

Development and validation of a clinically based risk calculator for the transdiagnostic prediction of psychosis

P Fusar-Poli, G Rutigliano, D Stahl, C Davies… - JAMA …, 2017 - jamanetwork.com
Importance The overall effect of At Risk Mental State (ARMS) services for the detection of
individuals who will develop psychosis in secondary mental health care is undetermined …

The clinical high-risk state for psychosis (CHR-P), version II

P Fusar-Poli - Schizophrenia bulletin, 2017 - academic.oup.com
Abstract The Clinical High-Risk state for psychosis (CHR-P) paradigm was introduced about
2 decades ago. Over this period of time accumulating knowledge has been gained …

Polygenic risk score contribution to psychosis prediction in a target population of persons at clinical high risk

DO Perkins, L Olde Loohuis, J Barbee… - American Journal of …, 2020 - Am Psychiatric Assoc
Objective: The 2-year risk of psychosis in persons who meet research criteria for a high-risk
syndrome is about 15%− 25%; improvements in risk prediction accuracy would benefit the …

Global research priorities for youth mental health

C Mei, J Fitzsimons, N Allen… - Early intervention in …, 2020 - Wiley Online Library
Aim Over the past two decades, the youth mental health field has expanded and advanced
considerably. Yet, mental disorders continue to disproportionately affect adolescents and …

Diagnostic and prognostic significance of brief limited intermittent psychotic symptoms (BLIPS) in individuals at ultra high risk

P Fusar-Poli, M Cappucciati, A De Micheli… - Schizophrenia …, 2017 - academic.oup.com
Abstract Background Brief Limited Intermittent Psychotic Symptoms (BLIPS) are key
inclusion criteria to define individuals at ultra high risk for psychosis (UHR). Their diagnostic …

Efficacy and acceptability of interventions for attenuated positive psychotic symptoms in individuals at clinical high risk of psychosis: a network meta-analysis

C Davies, J Radua, A Cipriani, D Stahl… - Frontiers in …, 2018 - frontiersin.org
Background: Attenuated positive psychotic symptoms represent the defining features of the
clinical high-risk for psychosis (CHR-P) criteria. The effectiveness of each available …

Epigenetic targets in schizophrenia development and therapy

A Wawrzczak-Bargieła, W Bilecki, M Maćkowiak - Brain Sciences, 2023 - mdpi.com
Schizophrenia is regarded as a neurodevelopmental disorder with its course progressing
throughout life. However, the aetiology and development of schizophrenia are still under …

Multivariate joint models for the dynamic prediction of psychosis in individuals with clinical high risk

TH Zhang, XC Tang, Y Zhang, LH Xu, YY Wei… - Asian Journal of …, 2023 - Elsevier
This study attempted to construct and validate dynamic prediction via multivariate joint
models and compare the prognostic performance of these models to both static and …