Nucleic acids carry the building plans of living systems. As such, they can be exploited to
make cells produce a desired protein, or to shut down the expression of endogenous genes …

The liver, in combination with a functional biliary system, is responsible for maintaining a
great number of vital body functions. However, acute and chronic liver diseases may lead to …

Hepatocyte-like cells from human embryonic stem cells (ESCs) and induced pluripotent
stem cells (iPSCs) are expected to be a useful source of cells drug discovery. Although we …

Mesenchymal stem cell (MSC)-based liver tissue engineering on nanofibrous scaffold holds
great promise for cell-based therapy in liver injuries and end-stage liver failure treatments …

The liver is the organ with the highest regenerative capacity in the human body. However,
various insults, including viral infections, alcohol or drug abuse, and metabolic overload …

Hepatocyte-like cells differentiated from human iPS cells (human iPS-HLCs) are expected to
be utilized in drug development and research. However, recent hepatic characterization of …

Introduction Due to a lack of adequate liver donors and post-surgical complications,
researchers propose that cell therapy should be an alternative treatment for patients with …

The liver is a target organ of life-threatening pathogens and prominently contributes to the
variation in drug responses and drug-induced liver injury among patients. Currently …

In recent years, gene therapy has received considerable interest as a potential method for
the treatment of numerous inherited and acquired diseases. However, successes have so …

Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
in adults and children. It is characterized by excessive accumulation of lipids in the …