Th17 cells that secrete the cytokines IL-17A and IL-17F and express lineage-specific
transcription factor RORC (RORγt in mice) represent a distinct lineage of CD4+ T cells …

The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin
(mTOR) signaling pathway has been implicated in various immune-mediated inflammatory …

It is thought that a Th1/Th17-weighted immune response plays a predominant role in the
pathogenesis of psoriasis. Our findings now indicate a link between IL-9, a Th2 and Th9 …

UV-based phototherapy (including psoralen plus UVA (PUVA), UVB and UVA1) has a long,
successful history in the management of numerous cutaneous disorders. Photoresponsive …

TGFβ1 was initially identified as a potent chemotactic cytokine to initiate inflammation, but
the autoimmune phenotype seen in TGFβ1 knockout mice reversed the dogma of TGFβ1 …

Psoriasis is a chronic, relapsing, autoimmune disorder of the skin affecting 2–3% of general
population. Approximately 30% of psoriasis patients are also affected with the psoriatic …

Background Glycolic acid (GA), commonly present in fruits, has been used to treat
dermatological diseases. Extensive exposure to solar ultraviolet B (UVB) irradiation plays a …

Psoriasis is a chronic inflammatory skin disease with a prevalence of 0.14% to 1.99%. The
underlying pathology is mainly driven by the abnormal immune responses including …

Rationale: Platelets are known to participate in vascular pathologies; however, their role in
neuroinflammatory diseases, such as multiple sclerosis (MS), is unknown. Autoimmune CD4 …

Polymorphous light eruption (PMLE) is the most common photodermatosis, with a
prevalence of up to approximately 20%, particularly among young women in temperate …