Gut microbiota and its metabolites in depression: from pathogenesis to treatment

L Liu, H Wang, X Chen, Y Zhang, H Zhang, P Xie - EBioMedicine, 2023 - thelancet.com
Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …

The role of gut microbiota in anxiety, depression, and other mental disorders as well as the protective effects of dietary components

RG Xiong, J Li, J Cheng, DD Zhou, SX Wu, SY Huang… - Nutrients, 2023 - mdpi.com
The number of individuals experiencing mental disorders (eg, anxiety and depression) has
significantly risen in recent years. Therefore, it is essential to seek prevention and treatment …

Clinical, gut microbial and neural effects of a probiotic add-on therapy in depressed patients: a randomized controlled trial

AC Schaub, E Schneider… - Translational …, 2022 - nature.com
A promising new treatment approach for major depressive disorder (MDD) targets the
microbiota-gut-brain (MGB) axis, which is linked to physiological and behavioral functions …

The gut microbiome in depression and potential benefit of prebiotics, probiotics and synbiotics: a systematic review of clinical trials and observational studies

SR Alli, I Gorbovskaya, JCW Liu, NJ Kolla… - International journal of …, 2022 - mdpi.com
An emerging body of literature demonstrates differences in the gut microbiome (GMB) of
patients with major depressive disorder (MDD) compared to healthy controls (HC), as well …

[HTML][HTML] An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders

A Borrego-Ruiz, JJ Borrego - Progress in Neuro-Psychopharmacology and …, 2024 - Elsevier
There is a lot of evidence establishing that nervous system development is related to the
composition and functions of the gut microbiome. In addition, the central nervous system …

[HTML][HTML] Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health

Z Wan, J Zheng, Z Zhu, L Sang, J Zhu, S Luo… - Frontiers in …, 2022 - frontiersin.org
Vitamin B consists of a group of water-soluble micronutrients that are mainly derived from
the daily diet. They serve as cofactors, mediating multiple metabolic pathways in humans. As …

Inflammation, lifestyle factors, and the microbiome‐gut‐brain Axis: relevance to depression and antidepressant action

F Donoso, JF Cryan… - Clinical …, 2023 - Wiley Online Library
Depression is considered a major public health concern, where existing pharmacological
treatments are not equally effective across all patients. The pathogenesis of depression …

Effect of probiotic supplementation on gut microbiota in patients with major depressive disorders: A systematic review

QX Ng, YL Lim, CYL Yaow, WK Ng, J Thumboo… - Nutrients, 2023 - mdpi.com
There is accumulating evidence on the beneficial effects of probiotic supplementation for
patients with depressive disorders. However, prior reviews on the topic have largely focused …

Gut microbiota metabolites in major depressive disorder—Deep insights into their pathophysiological role and potential translational applications

MA Ortega, MA Alvarez-Mon, C García-Montero… - Metabolites, 2022 - mdpi.com
The gut microbiota is a complex and dynamic ecosystem essential for the proper functioning
of the organism, affecting the health and disease status of the individuals. There is …

[HTML][HTML] The brain-gut-microbiota interplay in depression: A key to design innovative therapeutic approaches

A Varesi, LIM Campagnoli, S Chirumbolo… - Pharmacological …, 2023 - Elsevier
Depression is the most prevalent mental disorder in the world associated with huge socio-
economic consequences. While depressive-related symptoms are well known, the …