The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …
devastating consequences. While the medical community has gained insight into the …
Innate immunological pathways in COVID-19 pathogenesis
SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …
dysregulation of the innate immune system. This knowledge has emerged from the large …
Monocytes and Macrophages in COVID-19
COVID-19 is a contagious viral disease caused by SARS-CoV-2 that led to an ongoing
pandemic with massive global health and socioeconomic consequences. The disease is …
pandemic with massive global health and socioeconomic consequences. The disease is …
Systemic inflammatory response syndrome after surgery: mechanisms and protection
A Margraf, N Ludwig, A Zarbock… - Anesthesia & …, 2020 - journals.lww.com
The immune system is an evolutionary hallmark of higher organisms that defends the host
against invading pathogens and exogenous infections. This defense includes the …
against invading pathogens and exogenous infections. This defense includes the …
Long COVID: a review and proposed visualization of the complexity of long COVID
Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus–2 (SARS-CoV-2)
infection, or Long COVID, is a prevailing second pandemic with nearly 100 million affected …
infection, or Long COVID, is a prevailing second pandemic with nearly 100 million affected …
Innate immunity in protection and pathogenesis during coronavirus infections and COVID-19
RKS Malireddi, BR Sharma… - Annual Review of …, 2024 - annualreviews.org
The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2.
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19
AK Maher, KL Burnham, EM Jones, MMH Tan… - Nature …, 2022 - nature.com
Although alterations in myeloid cells have been observed in COVID-19, the specific
underlying mechanisms are not completely understood. Here, we examine the function of …
underlying mechanisms are not completely understood. Here, we examine the function of …
[HTML][HTML] COVID-19-associated acute respiratory distress syndrome (CARDS): Current knowledge on pathophysiology and ICU treatment–A narrative review
CA Pfortmueller, T Spinetti, RD Urman… - Best Practice & …, 2021 - Elsevier
Abstract (163 words) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
induces coronavirus-19 disease (COVID-19) and is a major health concern. Following two …
induces coronavirus-19 disease (COVID-19) and is a major health concern. Following two …
CytoSorb hemoperfusion markedly attenuates circulating cytokine concentrations during systemic inflammation in humans in vivo
A Jansen, NJB Waalders, DPT van Lier, M Kox… - Critical Care, 2023 - Springer
Abstract Background The CytoSorb hemoadsorption device has been demonstrated to be
capable of clearing inflammatory cytokines, but has not yet been shown to attenuate plasma …
capable of clearing inflammatory cytokines, but has not yet been shown to attenuate plasma …
Severe COVID-19 is characterized by the co-occurrence of moderate cytokine inflammation and severe monocyte dysregulation
B Bonnet, J Cosme, C Dupuis, E Coupez, M Adda… - …, 2021 - thelancet.com
Background SARS-CoV-2 has been responsible for considerable mortality worldwide, owing
in particular to pulmonary failures such as ARDS, but also to other visceral failures and …
in particular to pulmonary failures such as ARDS, but also to other visceral failures and …