Mammalian lungs have the ability to recognize external environments by sensing different
compounds in inhaled air. Pulmonary neuroendocrine cells (PNECs) are rare, multi …

The development of therapeutic approaches to treat lung disease requires an understanding
of both the normal and disease physiology of the lung. Although traditional experimental …

Endothelial cells (ECs) release ATP in response to shear stress, a fluid mechanical force
generated by flowing blood but, although its release has a crucial role in controlling a variety …

Evidence for a significant role and impact of purinergic signaling in normal and diseased
airways is now beyond dispute. The present review intends to provide the current state of …

Pulmonary neuroepithelial bodies are polymodal sensors widely distributed within the
airway mucosa of mammals and other species. Neuroepithelial body cells store and most …

The explosive growth of single-molecule techniques is transforming our understanding of
biology, helping to develop new physics inspired by emergent biological processes, and …

Respiratory diseases in their broad diversity need appropriate model systems to understand
the underlying mechanisms and enable development of new therapeutics. Additionally …

Replacement of lost or dysfunctional tissues by stem cells has recently raised many
investigations on therapeutic applications. Purinergic signaling has been shown to regulate …

Recent studies have identified epithelial stem and progenitor cell populations of the lung.
We are just beginning to understand the mechanisms that regulate their homeostatic …

During embryogenesis, the development of the respiratory tract is closely associated with
the formation of an extensive neuronal network. While the topic of respiratory innervation is …