Molecular farming–the slope of enlightenment

R Fischer, JF Buyel - Biotechnology advances, 2020 - Elsevier
Molecular farming can be defined as the use of plants to produce recombinant protein
products. The technology is now> 30 years old. The early promise of molecular farming was …

Plants as sources of natural and recombinant anti-cancer agents

JF Buyel - Biotechnology advances, 2018 - Elsevier
Herbal remedies were the first medicines used by humans due to the many
pharmacologically active secondary metabolites produced by plants. Some of these …

The production of recombinant pharmaceutical proteins in plants

JKC Ma, PMW Drake, P Christou - Nature reviews genetics, 2003 - nature.com
Imagine a world in which any protein, either naturally occurring or designed by man, could
be produced safely, inexpensively and in almost unlimited quantities using only simple …

Molecular farming in plants: host systems and expression technology

RM Twyman, E Stoger, S Schillberg, P Christou… - TRENDS in …, 2003 - cell.com
Plants provide an inexpensive and convenient system for the large-scale production of
valuable recombinant proteins. This principle has been demonstrated by the commercial …

Plant-based production of biopharmaceuticals

R Fischer, E Stoger, S Schillberg, P Christou… - Current opinion in plant …, 2004 - Elsevier
Plants are now gaining widespread acceptance as a general platform for the large-scale
production of recombinant proteins. The first plant-derived recombinant pharmaceutical …

[HTML][HTML] Very-large-scale production of antibodies in plants: The biologization of manufacturing

JF Buyel, RM Twyman, R Fischer - Biotechnology Advances, 2017 - Elsevier
Gene technology has facilitated the biologization of manufacturing, ie the use and
production of complex biological molecules and systems at an industrial scale. Monoclonal …

Plant molecular farming–integration and exploitation of side streams to achieve sustainable biomanufacturing

JF Buyel - Frontiers in plant science, 2019 - frontiersin.org
Plants have unique advantages over other systems such as mammalian cells for the
production of valuable small molecules and proteins. The benefits cited most often include …

Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures

J Xu, X Ge, MC Dolan - Biotechnology advances, 2011 - Elsevier
“Molecular farming” in plants with significant advantages in cost and safety is touted as a
promising platform for the production of complex pharmaceutical proteins. While whole-plant …

Production of heterologous proteins in plants: strategies for optimal expression

PN Desai, N Shrivastava, H Padh - Biotechnology advances, 2010 - Elsevier
Plants are a promising expression system for the production of heterologous proteins,
especially therapeutic proteins. Currently the majority of therapeutic proteins are produced …

Development of systems for the production of plant-derived biopharmaceuticals

KB Moon, JS Park, YI Park, IJ Song, HJ Lee, HS Cho… - Plants, 2019 - mdpi.com
Over the last several decades, plants have been developed as a platform for the production
of useful recombinant proteins due to a number of advantages, including rapid production …