[HTML][HTML] Sustained delivery approaches to improving adaptive immune responses

BS Ou, OM Saouaf, J Baillet, EA Appel - Advanced Drug Delivery Reviews, 2022 - Elsevier
The immune system is one of the most important, complex biological networks regulating
and protecting human health. Its precise modulation can prevent deadly infections and fight …

Advances in SARS-CoV-2 receptor-binding domain-based COVID-19 vaccines

X Guan, Y Yang, L Du - Expert review of vaccines, 2023 - Taylor & Francis
ABSTRACT Introduction The Coronavirus Disease 2019 (COVID-19) pandemic has caused
devastating human and economic costs. Vaccination is an important step in controlling the …

An in situ hydrogel-mediated chemo-immunometabolic cancer therapy

B Wang, J Chen, JS Caserto, X Wang, M Ma - Nature Communications, 2022 - nature.com
Metabolic reprogramming of the tumor microenvironment (TME) and poor immunogenicity
are two of the challenges that cancer immunotherapies have to overcome for improved …

Long-acting vaccine delivery systems

P Walvekar, P Kumar, YE Choonara - Advanced Drug Delivery Reviews, 2023 - Elsevier
Bolus vaccines are often administered multiple times due to rapid clearance and reduced
transportation to draining lymph nodes resulting in inadequate activation of T and B …

Inhalable hybrid nanovaccines with virus-biomimetic structure boost protective immune responses against SARS-CoV-2 variants

S Wang, P Ding, L Shen, D Fan, H Cheng… - Journal of …, 2024 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with different
antigenic variants, has posed a significant threat to public health. It is urgent to develop …

Injectable Hydrogel Mucosal Vaccine Elicits Protective Immunity against Respiratory Viruses

W Fu, M Guo, X Zhou, Z Wang, J Sun, Y An, T Guan… - ACS …, 2024 - ACS Publications
Intranasal vaccines, eliciting mucosal immune responses, can prevent early invasion,
replication, and transmission of pathogens in the respiratory tract. However, the effective …

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

K Yao, G Hong, X Yuan, W Kong, P Xia, Y Li, Y Chen… - Nano-Micro Letters, 2025 - Springer
Hydrogel scaffolds have numerous potential applications in the tissue engineering field.
However, tough hydrogel scaffolds implanted in vivo are seldom reported because it is …

Broad and Durable Humoral Responses Following Single Hydrogel Immunization of SARS‐CoV‐2 Subunit Vaccine

BS Ou, OM Saouaf, J Yan, TUJ Bruun… - Advanced …, 2023 - Wiley Online Library
Most vaccines require several immunizations to induce robust immunity, and indeed, most
SARS‐CoV‐2 vaccines require an initial two‐shot regimen followed by several boosters to …

Tailoring biomaterials for vaccine delivery

Y Zhuo, H Zeng, C Su, Q Lv, T Cheng, L Lei - Journal of …, 2024 - Springer
Biomaterials are substances that can be injected, implanted, or applied to the surface of
tissues in biomedical applications and have the ability to interact with biological systems to …

Nanosponges: an overlooked promising strategy to combat SARS-CoV-2

E Mostafavi, S Iravani, RS Varma - Drug Discovery Today, 2022 - Elsevier
Highlights•Nanosponges are explored for their antiviral delivery and biological
neutralization potentials.•Cellular nanosponges block interactions between SARS-CoV-2 …