Transient Receptor Potential (TRP) channels are a family of ion channels whose members
are distributed among all kinds of animals, from invertebrates to vertebrates. The importance …

In healthy connective tissues, mechanosensors trigger the generation of Ca2+ signals,
which enable cells to maintain the structure of the fibrillar collagen matrix through …

Cardiac macrophages represent a heterogeneous cell population with distinct origins,
dynamics, and functions. Recent studies have revealed that CC Chemokine Receptor 2 …

The vascular endothelium is a broadly distributed and highly specialized organ. The
endothelium has a number of functions including the control of blood vessels diameter …

Background and Purpose The TRPV4 ion channels are Ca2+ permeable, non‐selective
cation channels that mediate large, but highly localized, Ca2+ signals in the endothelium …

The role of Ca2+ signalling in fibroblasts is of great interest in fibrosis‐related diseases.
Intracellular free Ca2+ ([Ca2+] i) is a ubiquitous secondary messenger, regulating a number …

Metabolic syndrome is a significant worldwide public health challenge and is inextricably
linked to adverse renal and cardiovascular outcomes. The inhibition of the transient receptor …

Amphiregulin (AREG) is a transmembrane glycoprotein recently implicated in kidney
fibrosis. Previously, we reported that the AREG-targeting Self-Assembled-Micelle inhibitory …

Transient receptor potential channel subfamily C, member 6 (TRPC6), a non-selective cation
channel that controls influx of Ca2+ and other monovalent cations into cells, is widely …

Ubiquitin (Ub)-mediated regulation of plasmalemmal ion channel activity canonically occurs
via stimulation of endocytosis. Whether ubiquitination can modulate channel activity by …