Tumor-associated macrophages (TAM) are one of the most abundant cell types in many
solid tumors and typically exert protumor effects. This has led to an interest in macrophage …

Immune checkpoint blockade (ICB) of the PD-1 pathway revolutionized the survival forecast
for advanced non-small cell lung cancer (NSCLC). Yet, the majority of PD-L1+ NSCLC …

Mouse tumor models are essential in cancer research, especially in elucidating malignancy,
developing prevention, diagnosis, and new therapeutic approaches. Nowadays, due to …

Breast cancer (BC) is the most diagnosed cancer type, accounting for one in eight cancer
diagnoses worldwide. Epidemiological studies have shown that obesity is associated with …

Mouse models for the study of pancreatic ductal adenocarcinoma (PDAC) are well-
established and representative of many key features observed in human PDAC. To monitor …

Simple Summary Leukemic growth results in selective silencing of gene transcripts involved
in immune detection, differentiation, and apoptosis. Hypomethylating agents (HMAs), such …

Here, we present a protocol to generate a murine model of liver metastasis by directly
injecting tumor cells into the portal vein under ultrasound guidance. We describe steps for …

Some properties of Salmonella-infected cells overlap with immunogenic cell death. In this
study, we demonstrated that intracellular infection of melanoma with Salmonella …

Transient delivery of CRISPR-Cas9 ribonucleoproteins (RNPs) into the central nervous
system (CNS) for therapeutic genome editing could avoid limitations of viral vector-based …

Orthotopic non-small cell lung cancer (NSCLC) mice models are important for establishing
translatability of in vitro results. However, most orthotopic lung models do not produce …