Interplay between eskape pathogens and immunity in skin infections: An overview of the major determinants of virulence and antibiotic resistance

GHR Vale de Macedo, GDE Costa, ER Oliveira… - Pathogens, 2021 - mdpi.com
The skin is the largest organ in the human body, acting as a physical and immunological
barrier against pathogenic microorganisms. The cutaneous lesions constitute a gateway for …

Using genomics to understand meticillin- and vancomycin-resistant Staphylococcus aureus infections

SG Giulieri, SYC Tong… - Microbial …, 2020 - microbiologyresearch.org
Resistance to meticillin and vancomycin in Staphylococcus aureus significantly complicates
the management of severe infections like bacteraemia, endocarditis or osteomyelitis. Here …

MRSA lineage USA300 isolated from bloodstream infections exhibit altered virulence regulation

S Dyzenhaus, MJ Sullivan, B Alburquerque, D Boff… - Cell host & …, 2023 - cell.com
The epidemic community-associated methicillin-resistant Staphylococcus aureus (CA-
MRSA) USA300 lineage has recently become a leading cause of hospital-associated …

Genome Plasticity of agr-Defective Staphylococcus aureus during Clinical Infection

DR Altman, MJ Sullivan, KI Chacko… - Infection and …, 2018 - Am Soc Microbiol
Therapy for bacteremia caused by Staphylococcus aureus is often ineffective, even when
treatment conditions are optimal according to experimental protocols. Adapted subclones …

Whole-genome epidemiology, characterisation, and phylogenetic reconstruction of Staphylococcus aureus strains in a paediatric hospital

S Manara, E Pasolli, D Dolce, N Ravenni, S Campana… - Genome medicine, 2018 - Springer
Background Staphylococcus aureus is an opportunistic pathogen and a leading cause of
nosocomial infections. It can acquire resistance to all the antibiotics that entered the clinics …

Novel insights into the enterotoxigenic potential and genomic background of Staphylococcus aureus isolated from raw milk

D Chieffi, F Fanelli, GS Cho, J Schubert, G Blaiotta… - Food …, 2020 - Elsevier
In this study, 53 Staphylococcus (S.) aureus strains were typed by 16S–23S rDNA intergenic
spacer region (ISR) typing and staphylococcal enterotoxin gene (SEg) typing for all the …

The Plasmidomic Landscape of Clinical Methicillin-Resistant Staphylococcus aureus Isolates from Malaysia

EI Al-Trad, CH Chew, AM Che Hamzah, Z Suhaili… - Antibiotics, 2023 - mdpi.com
Methicillin-resistant Staphylococcus aureus (MRSA) is a priority nosocomial pathogen with
plasmids playing a crucial role in its genetic adaptability, particularly in the acquisition and …

Exploiting species specificity to understand the tropism of a human-specific toxin

KM Boguslawski, AN McKeown, CJ Day, KA Lacey… - Science …, 2020 - science.org
Many pathogens produce virulence factors that are specific toward their natural host.
Clinically relevant methicillin-resistant Staphylococcus aureus (MRSA) isolates are highly …

A complete genome screening program of clinical methicillin-resistant Staphylococcus aureus isolates identifies the origin and progression of a neonatal intensive …

MJ Sullivan, DR Altman, KI Chacko… - Journal of clinical …, 2019 - Am Soc Microbiol
Whole-genome sequencing (WGS) of Staphylococcus aureus is increasingly used as part of
infection prevention practices. In this study, we established a long-read technology-based …

Hierarchy of human IgG recognition within the Staphylococcus aureus immunome

EE Radke, SM Brown, AJ Pelzek, Y Fulmer… - Scientific Reports, 2018 - nature.com
Staphylococcus aureus is an opportunistic pathogen that causes a range of serious
infections associated with significant morbidity, by strains increasingly resistant to antibiotics …