Short-chain fatty acids as a potential treatment for infections: a closer look at the lungs

MG Machado, V Sencio, F Trottein - Infection and immunity, 2021 - Am Soc Microbiol
Short-chain fatty acids (SCFAs) are the main metabolites produced by the gut microbiota via
the fermentation of complex carbohydrates and fibers. Evidence suggests that SCFAs play a …

Drugs and bugs: the gut-brain axis and substance use disorders

S Simpson, R Mclellan, E Wellmeyer, F Matalon… - Journal of Neuroimmune …, 2022 - Springer
Substance use disorders (SUDs) represent a significant public health crisis. Worldwide,
5.4% of the global disease burden is attributed to SUDs and alcohol use, and many more …

Linking human milk oligosaccharides, infant fecal community types, and later risk to require antibiotics

B Berger, N Porta, F Foata, D Grathwohl, M Delley… - MBio, 2020 - Am Soc Microbiol
Human milk oligosaccharides (HMOs) may provide health benefits to infants partly by
shaping the development of the early-life intestinal microbiota. In a randomized double …

Microbiota-derived short-chain fatty acids promote LAMTOR2-mediated immune responses in macrophages

T Wu, H Li, C Su, F Xu, G Yang, K Sun, M Xu, N Lv… - Msystems, 2020 - Am Soc Microbiol
Klebsiella pneumoniae is a common cause of human-pneumonia-derived sepsis with high
morbidity and mortality. The microbiota promotes and maintains host immune homeostasis …

The intestinal microbiome primes host innate immunity against enteric virus systemic infection through type I interferon

XL Yang, G Wang, JY Xie, H Li, SX Chen, W Liu… - MBio, 2021 - Am Soc Microbiol
Intestinal microbiomes are of vital importance in antagonizing systemic viral infection.
However, very little literature has shown whether commensal bacteria play a crucial role in …

[HTML][HTML] Changes in rumen fermentation and bacterial community in lactating dairy cows with subacute rumen acidosis following rumen content transplantation

YY Mu, WP Qi, T Zhang, JY Zhang, SJ Mei… - Journal of Dairy …, 2021 - Elsevier
Rumen microbiota intervention has long been used to cure ruminal indigestion in production
and has recently become a research hotspot. However, how it controls the remodeling of …

Mild SARS-CoV-2 infection results in long-lasting microbiota instability

V Upadhyay, RK Suryawanshi, P Tasoff… - Mbio, 2023 - Am Soc Microbiol
Viruses targeting mammalian cells can indirectly alter the gut microbiota, potentially
compounding their phenotypic effects. Multiple studies have observed a disrupted gut …

[HTML][HTML] Novel GPR43 agonists exert an anti-inflammatory effect in a colitis model

BO Park, JS Kang, S Paudel, SG Park… - Biomolecules & …, 2022 - ncbi.nlm.nih.gov
GPR43 (also known as FFAR2), a metabolite-sensing G-protein-coupled receptor stimulated
by short-chain fatty acid (SCFA) ligands is involved in innate immunity and metabolism …

Supplementing the diet with sodium propionate suppresses the severity of viral immuno-inflammatory lesions

D Sumbria, E Berber, BT Rouse - Journal of virology, 2021 - Am Soc Microbiol
This report evaluates a dietary manipulation approach to suppress the severity of ocular
infections caused by herpes simplex virus infection. The virus causes chronic damage to the …

Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections

Q Xie, Q Li, H Fang, R Zhang, H Tang… - Clinical Reviews in Allergy …, 2024 - Springer
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, modulate
immune cell functions, particularly macrophages. This review explores the potential …