In the early 1950s, Austin and Chang independently described the changes that are
required for the sperm to fertilize oocytes in vivo. These changes were originally grouped …

Mammalian sperm cells must respond to cues originating from along the female
reproductive tract and from the layers of the egg in order to complete their fertilization …

Calcium and cyclic nucleotides have crucial roles in mammalian fertilization, but the
molecules comprising the Ca2+-permeation pathway in sperm motility are poorly …

A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

Mammalian spermatozoa become motile at ejaculation, but before they can fertilize the egg,
they must acquire more thrust to penetrate the cumulus and zona pellucida. The forceful …

CatSper family proteins are putative ion channels expressed exclusively in membranes of
the sperm flagellum and required for male fertility. Here, we show that mouse CatSper1 is …

Calcium ions play a primary role in the regulation of sperm cell behavior. We report finding a
voltage-gated ion channel (CatSper2) that is expressed in male germ cells but not in other …

A number of physiological events, such as sperm hyperactivation, chemotaxis towards the
egg, capacitation and acrosome reaction, are triggered by activation of sperm ion channels …

In mammals, Ca2+ and ions play a critical role in the regulation of sperm function, most likely
by regulation of cAMP levels. Mammalian germ cells contain a soluble adenylyl cyclase …

Fertilization is the process by which haploid gametes, sperm and egg, unite to produce a
genetically distinct individual. Interest in this area has exploded in recent years. Here are …