Peptides as multifunctional players in cancer therapy

SMP Vadevoo, S Gurung, HS Lee… - … & Molecular Medicine, 2023 - nature.com
Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely,
peptides demonstrate higher efficiency in tissue penetration and cell internalization than …

Human prostate cancer risk factors

DG Bostwick, HB Burke, D Djakiew… - … Journal of the …, 2004 - Wiley Online Library
Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and their receptors in humans

CK Cheng, PCK Leung - Endocrine reviews, 2005 - academic.oup.com
In human beings, two forms of GnRH, termed GnRH-I and GnRH-II, encoded by separate
genes have been identified. Although these hormones share comparable cDNA and …

Cancer chemotherapy based on targeting of cytotoxic peptide conjugates to their receptors on tumors

AV Schally, A Nagy - European journal of endocrinology, 1999 - academic.oup.com
In view of non-specific toxicity of most chemotherapeutic agents against normal cells, the
development of targeted chemotherapy is warranted. Efficient targeting of chemotherapeutic …

High affinity binding and direct antiproliferative effects of LHRH analogues in human ovarian cancer cell lines

G Emons, O Ortmann, M Becker, G Irmer, B Springer… - Cancer Research, 1993 - AACR
Recently, specific binding sites for luteinizing hormone releasing hormone (LHRH) and its
analogues have been demonstrated in biopsy samples of human epithelial ovarian cancer …

Targeting of cytotoxic luteinizing hormone-releasing hormone analogs to breast, ovarian, endometrial, and prostate cancers

A Nagy, AV Schally - Biology of reproduction, 2005 - academic.oup.com
Targeted chemotherapy is a modern approach aimed at increasing the efficacy of systemic
chemotherapy and reducing its side effects. The peptide receptors expressed primarily on …

Quantitative gonadotropin-releasing hormone gene expression and immunohistochemical localization in human endometrium throughout the menstrual cycle

F Raga, EM Casan, JS Kruessel, Y Wen… - Biology of …, 1998 - academic.oup.com
GnRH is one of the paracrine/autocrine regulators of hCG secretion produced by the human
trophoblast during pregnancy. We hypothesized that GnRH may play a role in the …

[HTML][HTML] Conservative treatment may be beneficial for young women with atypical endometrial hyperplasia or endometrial adenocarcinoma

P Jadoul, J Donnez - Fertility and sterility, 2003 - Elsevier
OBJECTIVE: To evaluate whether an alternative treatment to radical hysterectomy exists for
young women with endometrial adenocarcinoma. DESIGN: A review of the literature (70 …

The role of gonadotropin-releasing hormone (GnRH) in endometrial cancer

G Emons, C Gründker - Cells, 2021 - mdpi.com
Endometrial cancer (EC) is one of the most common gynecological malignancies.
Gonadotropin releasing hormone (GnRH) is a decapeptide first described to be secreted by …

Gonadotropin‐releasing hormone: GnRH receptor signaling in extrapituitary tissues

LWT Cheung, AST Wong - The FEBS journal, 2008 - Wiley Online Library
Gonadotropin‐releasing hormone (GnRH) has historically been known as a pituitary
hormone; however, in the past few years, interest has been raised in locally produced …