The prostaglandins constitute a family of lipids of 20 carbon atoms that derive from
polyunsaturated fatty acids such as arachidonic acid. Traditionally, prostaglandins have …

Arachidonic acid (AA), an n‐6 essential fatty acid, is a major component of mammalian cells
and can be released by phospholipase A2. Accumulating evidence indicates that AA plays …

Lung cancer is one of the most common cancers worldwide and a leading cause of cancer-
related deaths. Macrophages play a key role in the immune response and the tumour …

Simple Summary There is no doubt that the need for new effective methods of cancer
treatment remains challenging, as cancer is the second cause of death based on the …

Head and neck squamous cell carcinoma (HNSCC) arises from the epithelial lining of the
oral cavity, hypopharynx, oropharynx, and larynx. There are several potential risk factors that …

Head and neck squamous cell carcinoma (HNSCC), which originates in the head or neck
tissues, is characterized by high rates of recurrence and metastasis. Inflammation is …

Smoking is a documented risk factor for cancer, eg, gastric cancer. Nicotine, the principal
tobacco alkaloid, would exert its role of contribution to gastric cancer development and …

Introduction COX-2 is a crucial enzyme in the manufacture of prostaglandins. The enzyme's
metabolites might have an important function as regulators of the inflammatory response …

Fenamates as classical nonsteroidal anti‐inflammatory agents are widely used for relieving
pain. Preclinical studies and epidemiological data highlight their chemo‐preventive and …

Abstract Dual cyclooxygenase 2/15-lipoxygenase inhibitors constitute a valuable alternative
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …