The cell cycle is a collection of events by which cellular components such as genetic
materials and cytoplasmic components are accurately divided into two daughter cells. The …

A growing amount of evidence indicates that the neuronally expressed developmentally
downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a …

Gastric cancer is a highly malignant tumor with poor survival rate. Ferroptosis, a newly
defined regulated cell death, is closely related to several tumors. Introduction of ferroptosis is …

Breast cancer (BC) is the leading cause of cancer death in women. This disease is
heterogeneous, with clinical subtypes being estrogen receptor-α (ER-α) positive, having …

JCI - Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer
and brain metastases Go to JCI Insight About Editors Consulting Editors For authors Publication …

N-myc downstream regulated gene-1 (NDRG1) has been identified as a putative metastasis
suppressor gene and proved to be a key player in cancer spreading and proliferation in our …

ABSTRACT NEDD4 is an E3 ubiquitin ligase that recognizes substrates through protein–
protein interactions and is involved in cancer development. This study aimed to elucidate the …

Cancer is a deadly disease worldwide, with an anticipated 19.3 million new cases and 10.0
million deaths occurring in 2020 according to GLOBOCAN 2020. It is well established that …

Recent studies have shown that lycorine, a natural alkaloid compound, plays its anti-cancer
role in several human malignancies including bladder cancer. However, the molecular …

Several members of the ubiquitin-specific proteases (USPs) family have been revealed to
regulate the progression of osteoarthritis (OA). The current study aimed to investigate the …