[HTML][HTML] IκB kinase β (IKKβ): Structure, transduction mechanism, biological function, and discovery of its inhibitors
J Zhang, R Zhang, W Li, XC Ma, F Qiu… - International Journal of …, 2023 - ncbi.nlm.nih.gov
The effective approach to discover innovative drugs will ask natural products for answers
because of their complex and changeable structures and multiple biological activities …
because of their complex and changeable structures and multiple biological activities …
Molecular regulation mechanisms and interactions between reactive oxygen species and mitophagy
P Fan, XH Xie, CH Chen, X Peng, P Zhang… - DNA and Cell …, 2019 - liebertpub.com
The generation of reactive oxygen species (ROS) in response to oxidative stress has
important effects on cell development, normal function, and survival. It may cause oxidative …
important effects on cell development, normal function, and survival. It may cause oxidative …
Pristimerin protects against doxorubicin-induced cardiotoxicity and fibrosis through modulation of Nrf2 and MAPK/NF-kB signaling pathways
DS El-Agamy, KM El-Harbi, S Khoshhal… - Cancer management …, 2018 - Taylor & Francis
Background/purpose Pristimerin (Pris) is triterpenoid compound with many biological effects.
Until now, nothing is known about its effect on doxorubicin (DOX)-induced cardiotoxicity …
Until now, nothing is known about its effect on doxorubicin (DOX)-induced cardiotoxicity …
Structural characterization and immunomodulating activity of polysaccharide from Dendrobium officinale
TB He, YP Huang, L Yang, TT Liu, WY Gong… - International journal of …, 2016 - Elsevier
Abstract A neutral heteropolysaccharide (DOP-1-1) consisted by mannose and glucose (5.9:
1) with an average molecular weight at about 1.78× 10 5 Da was purified from Dendrobium …
1) with an average molecular weight at about 1.78× 10 5 Da was purified from Dendrobium …
Natural compounds with dual antimicrobial and anti-inflammatory effects
A Sychrová, I Koláriková, M Žemlička, K Šmejkal - Phytochemistry reviews, 2020 - Springer
Increasing antimicrobial resistance, together with the occurrence of side effects of NSAIDs or
glucocorticoids represents certain motivation to search for new natural dual antimicrobial …
glucocorticoids represents certain motivation to search for new natural dual antimicrobial …
Pristimerin inhibits MMP-9 expression and cell migration through attenuating NOX/ROS-dependent NF-κB activation in rat brain astrocytes challenged with LPS
Purpose Neuroinflammation plays a crucial role in neurodegenerative diseases. Matrix
metalloproteinases (MMPs) are a landmark of neuroinflammation. Lipopolysaccharide (LPS) …
metalloproteinases (MMPs) are a landmark of neuroinflammation. Lipopolysaccharide (LPS) …
Effect of pristimerin on apoptosis through activation of ROS/endoplasmic reticulum (ER) stress-mediated noxa in colorectal cancer
Q Zhao, Y Bi, J Guo, Y Liu, J Zhong, Y Liu, L Pan… - Phytomedicine, 2021 - Elsevier
Background Pristimerin, a natural quinonemethid triterpenoid found in different spp. of
Celastraceae and Hippocrateaceae families, has been reported to exhibit potent antitumor …
Celastraceae and Hippocrateaceae families, has been reported to exhibit potent antitumor …
Necrostatin-1 protects against paraquat-induced cardiac contractile dysfunction via RIP1-RIP3-MLKL-dependent necroptosis pathway
L Zhang, Q Feng, T Wang - Cardiovascular Toxicology, 2018 - Springer
Paraquat is a highly toxic prooxidant that triggers oxidative stress and multi-organ failure
including that of the heart. To date, effective treatment of paraquat toxicity is still not …
including that of the heart. To date, effective treatment of paraquat toxicity is still not …
Protective effect of pristimerin against LPS-induced acute lung injury in mice
Pristimerin (Pris) is a triterpenoid derivative obtained from Celastraceae and
Hippocrateaceae families. This compound has been extensively tested for its potent anti …
Hippocrateaceae families. This compound has been extensively tested for its potent anti …
Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation
Q Zhao, Y Bi, J Guo, Y Liu, J Zhong, L Pan… - Acta Pharmacologica …, 2021 - nature.com
Excessive activation of NLRP3 inflammasome is associated with the pathogenesis of
inflammatory diseases. Pristimerin (Pri) is a quinonoid triterpene derived from traditional …
inflammatory diseases. Pristimerin (Pri) is a quinonoid triterpene derived from traditional …