Mutations in the TP53 tumour suppressor gene are very frequent in cancer, and attempts to
restore the functionality of p53 in tumours as a therapeutic strategy began decades ago …

Increasing evidence indicates that the tumor microenvironment has critical roles in all
aspects of cancer biology, including growth, angiogenesis, metastasis and progression …

Cancer is a systemic disease encompassing multiple components of both tumor cells
themselves and host stromal cells. It is now clear that stromal cells in the tumor …

Stromal heterogeneity of tumor microenvironment (TME) plays a crucial role in malignancy
and therapeutic resistance. Cancer-associated fibroblasts (CAFs) are one of the major …

Stromal cells within the tumor microenvironment are essential for tumor progression and
metastasis. Surprisingly little is known about the factors that drive the transcriptional …

Adipocytes account for the largest proportion among the cells that comprise breast tissue;
therefore, they are considered to be a critical cell type in the tumor microenvironment of …

G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …

As a key transcription factor, the evolutionarily conserved tumor suppressor p53 (encoded
by TP 53) plays a central role in response to various cellular stresses. A variety of biological …

Chemokines play a paramount role in the tumor progression. Chronic inflammation
promotes tumor formation. Both tumor cells and stromal cells elaborate chemokines and …

In this study, high-throughput microRNA (miRNA) expression analysis revealed that the
expression of miR-140 was associated with chemosensitivity in osteosarcoma tumor …