Alzheimer's disease (AD) is the most common type of dementia affecting regions of the
central nervous system that exhibit synaptic plasticity and are involved in higher brain …

Regulated exocytosis is the main mechanism utilized by specialized secretory cells to
deliver molecules to the cell surface by virtue of membranous containers (ie, secretory …

The blood vessel wall has a number of self‐healing properties, enabling it to minimize blood
loss and prevent or overcome infections in the event of vascular trauma. Endothelial cells …

It has become increasingly clear that the accumulation of proteins in specific regions of the
plasma membrane can facilitate cellular communication. These regions, termed signaling …

Pharmaceutical manipulation of cAMP levels exerts beneficial effects through the regulation
of the exchange protein activated by cAMP (EPAC) and protein kinase A (PKA) signalling …

In humans, vWF levels predict the risk of myocardial infarction and thrombosis; however, the
factors that influence vWF levels are not completely understood. Recent genome-wide …

Rickettsiae are responsible for some of the most devastating human infections. A high
infectivity and severe illness after inhalation make some rickettsiae bioterrorism threats. We …

The second messenger cAMP plays a central role in mediating vascular smooth muscle
relaxation in response to vasoactive transmitters and in strengthening endothelial cell–cell …

In this study, we investigated the roles of Epac1 in pathological angiogenesis and its
potential as a novel therapeutic target for the treatment of vasoproliferative diseases …

Endothelial cells serve as gatekeepers of vascular hemostasis and local inflammatory
reactions. They can rapidly respond to changes in the environment, caused, for example, by …