Vascular endothelial cell biology: an update

A Krüger-Genge, A Blocki, RP Franke… - International journal of …, 2019 - mdpi.com
The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner
cellular lining of arteries, veins and capillaries and therefore is in direct contact with the …

Endothelial responses in sepsis

J Joffre, J Hellman, C Ince… - American journal of …, 2020 - atsjournals.org
Endothelial cells (ECs) are vascular, nonconventional immune cells that play a major role in
the systemic response after bacterial infection to limit its dissemination. Triggered by …

[HTML][HTML] Derangement of the endothelial glycocalyx in sepsis

T Iba, JH Levy - Journal of Thrombosis and Haemostasis, 2019 - Elsevier
The vascular endothelial surface is coated by the glycocalyx, a ubiquitous gel‐like layer
composed of a membrane‐binding domain that contains proteoglycans, glycosaminoglycan …

Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases

BF Becker, M Jacob, S Leipert… - British journal of …, 2015 - Wiley Online Library
The endothelial glycocalyx has a profound influence at the vascular wall on the transmission
of shear stress, on the maintenance of a selective permeability barrier and a low hydraulic …

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

EP Schmidt, Y Yang, WJ Janssen, A Gandjeva… - Nature medicine, 2012 - nature.com
Sepsis, a systemic inflammatory response to infection, commonly progresses to acute lung
injury (ALI), an inflammatory lung disease with high morbidity. We postulated that sepsis …

Endothelial glycocalyx degradation in critical illness and injury

EK Patterson, G Cepinskas, DD Fraser - Frontiers in Medicine, 2022 - frontiersin.org
The endothelial glycocalyx is a gel-like layer on the luminal side of blood vessels that is
composed of glycosaminoglycans and the proteins that tether them to the plasma …

Modulation of endothelial glycocalyx structure under inflammatory conditions

H Kolářová, B Ambrůzová… - Mediators of …, 2014 - Wiley Online Library
The glycocalyx of the endothelium is an intravascular compartment that creates a barrier
between circulating blood and the vessel wall. The glycocalyx is suggested to play an …

Role of reactive oxygen and nitrogen species in the vascular responses to inflammation

PR Kvietys, DN Granger - Free Radical Biology and Medicine, 2012 - Elsevier
Inflammation is a complex and potentially life-threatening condition that involves the
participation of a variety of chemical mediators, signaling pathways, and cell types. The …

Endothelial mechanobiology in atherosclerosis

X Wang, Y Shen, M Shang, X Liu… - Cardiovascular …, 2023 - academic.oup.com
Cardiovascular disease (CVD) is a serious health challenge, causing more deaths
worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …

Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus

LN Broekhuizen, BA Lemkes, HL Mooij, MC Meuwese… - Diabetologia, 2010 - Springer
Aims/hypothesis Endothelial glycocalyx perturbation contributes to increased vascular
permeability. In the present study we set out to evaluate whether:(1) glycocalyx is perturbed …