Preclinical Study in Mouse Thymus and Thymocytes: Effects of Treatment with a Combination of Sodium Dichloroacetate and Sodium Valproate on Infectious …

D Stakišaitis, L Kapočius, E Kilimaitė, D Gečys… - Pharmaceutics, 2023 - mdpi.com
The research presents data from a preclinical study on the anti-inflammatory effects of a
sodium dichloroacetate and sodium valproate combination (DCA–VPA). The 2-week …

Inhibiting Leishmania donovani Sterol Methyltransferase to Identify Lead Compounds Using Molecular Modelling

PO Sakyi, SK Kwofie, JK Tuekpe, TM Gwira, E Broni… - Pharmaceuticals, 2023 - mdpi.com
The recent outlook of leishmaniasis as a global public health concern coupled with the
reportage of resistance and lack of efficacy of most antileishmanial drugs calls for a …

Innovative, rapid, high-throughput method for drug repurposing in a pandemic—A case study of SARS-CoV-2 and COVID-19

SO Bello, A Yunusa, AA Adamu, MU Imam… - Frontiers in …, 2023 - frontiersin.org
Several efforts to repurpose drugs for COVID-19 treatment have largely either failed to
identify a suitable agent or agents identified did not translate to clinical use. Reasons that …

Molecular mechanism of Dang-Shen-Yu-Xing decoction against Mycoplasma bovis pneumonia based on network pharmacology, molecular docking, molecular …

M Yang, F Yang, Y Guo, F Liu, Y Li, Y Qi… - Frontiers in Veterinary …, 2024 - frontiersin.org
Mycoplasma bovis pneumonia is a highly contagious respiratory infection caused by
Mycoplasma bovis. It is particularly prevalent in calves, posing a significant threat to animal …

[HTML][HTML] Improving the binding affinity of plastic degrading cutinase with polyethylene terephthalate (PET) and polyurethane (PU); an in-silico study

DS VL, G Rajmohan, SB Roshine, S Srivaishnavi… - Heliyon, 2025 - cell.com
Plastic pollution is a worrying problem, and its degradation is a laborious process. Although
enzymatic plastic breakdown is a sustainable method, drawbacks such as numerous plastic …

Identification of coastal pesticide pollutants as potent inhibitors of Bacillus pasteurii urease mediated calcium carbonate precipitation: a computational approach

A Ganapathy Vilasam Sreekala, KK Gupta… - Journal of …, 2024 - Taylor & Francis
Microbially induced calcite precipitation (MICP) through urease enzyme has attained a lot of
recognition in various fields of civil engineering and geotechnology for stabilizing the …

Mechanism to disrupt ESCRT-mediated intracellular trafficking through Vps28-small molecules interaction: an in silico approach

BP Gurjar, AS Rathore, R Yadav, R Jain… - Journal of …, 2024 - Taylor & Francis
Abstract The ESCRT (Endosomal Sorting Complex Required for Transport) machinery
comprising protein complexes ESCRT-0 to ESCRT-III and Vps4 plays a pivotal role in …

Innovative, rapid, high-throughput method for drug repurposing in a pandemic – a case study of SARS-CoV-2 and COVID-19

SO Bello, A Yunusa, AA Adamu, MU Imam, MB Bello… - bioRxiv, 2022 - biorxiv.org
Several efforts to repurpose drugs for COVID-19 treatment have largely either failed to
identify a suitable agent or agents identified did not translate to clinical use; either because …