Biologics for chronic rhinosinusitis—A modern option for therapy

R Cergan, ON Berghi, M Dumitru, D Vrinceanu… - Life, 2023 - mdpi.com
Chronic rhinosinusitis (CRS) is an important ENT pathology which affects about 5–12% of
the general population. The treatment of CRS can be pharmacological (nasal sprays …

Regional specialization within the mammalian respiratory immune system

DPH van Konijnenburg, PA Nigrovic, I Zanoni - Trends in Immunology, 2024 - cell.com
The respiratory tract is exposed to infection from inhaled pathogens, including viruses,
bacteria, and fungi. So far, a comprehensive assessment that integrates common and …

[HTML][HTML] Serum exosomal miR-141-3p and miR-3679-5p levels associated with endotype and postoperative recurrence in chronic rhinosinusitis with nasal polyps

G Wang, Z Liu, J Zhan, R Li, Y Ye, Y Qi, X Wei… - World Allergy …, 2024 - Elsevier
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory
disease. Exosomes were involved in different inflammatory diseases, but their roles in …

Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions

Y Liu, W Lv, W Wang - Clinical Reviews in Allergy & Immunology, 2024 - Springer
Chronic rhinosinusitis (CRS) is a heterogenic disease characterized by persistent mucosal
inflammation of the upper airway. Researches of CRS have progressed from phenotype …

[HTML][HTML] Progress in Cellular Mechanisms of Chronic Rhinosinusitis

JX Li, ZC Wang, Z Liu, Y Yao - Fundamental Research, 2024 - Elsevier
Chronic rhinosinusitis (CRS) represents one of the most common chronic conditions
occurring in the nasal cavity and sinuses, affecting approximately 10% of the global …

The role of fibroblast in chronic rhinosinusitis with nasal polyps: a key player in the inflammatory process

Q Zhang, J Jiao, X Wang, L Zhang - Expert Review of Clinical …, 2024 - Taylor & Francis
Introduction Fibroblasts are the primary supporting cells in connective tissue and have long
been thought to contribute to chronic rhinosinusitis with nasal polyps (CRSwNP) by …

Shared genetic etiology between hypothyroidism and complex diseases: a large-scale genome-wide cross-trait analysis

S Li, M Gong - medRxiv, 2024 - medrxiv.org
Hypothyroidism is a common condition of thyroid hormone insufficiency, and there is
growing evidence of its link with additional diseases. It remains unclear whether these …

Unifying the airway through multiomics

AR Sedaghat, KM Phillips - Annals of Allergy, Asthma & Immunology, 2024 - annallergy.org
The relationship between inflammatory diseases of the lower and upper airways, the unified
airway hypothesis, has been long recognized. Interactions between comorbid asthma and …