The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …

Protein therapeutics, such as monoclonal antibodies, enzymes and toxins, hold significant
promise for improving human health. However, repeated administration of protein …

Background Class I major histocompatibility complex (MHC) molecules bind, and present to
T cells, short peptides derived from intracellular processing of proteins. The peptide …

Computational vaccinology includes epitope mapping, antigen selection, and immunogen
design using computational tools. Tools that facilitate the in silico prediction of immune …

Protein therapeutics hold a prominent and rapidly expanding place among medicinal
products. Purified blood products, recombinant cytokines, growth factors, enzyme …

We have identified at least 2 highly promiscuous major histocompatibility complex class II T-
cell epitopes in the Fc fragment of IgG that are capable of specifically activating CD4+ …

One of the great surprises of the biologics revolution has been the discovery that
recombinant human proteins, including monoclonals of human origin, can cause immune …

Vaccine informatics is an emerging research area that focuses on development and
applications of bioinformatics methods that can be used to facilitate every aspect of the …

Currently, there is a significant rise in the development and clinical use of a unique class of
pharmaceuticals termed as Biopharmaceuticals or Biologics, in the management of a range …

Computational vaccine design, also known as computational vaccinology, encompasses
epitope mapping, antigen selection and immunogen design using computational tools. The …