Advances in PET imaging of cancer

J Schwenck, D Sonanini, JM Cotton… - Nature Reviews …, 2023 - nature.com
Molecular imaging has experienced enormous advancements in the areas of imaging
technology, imaging probe and contrast development, and data quality, as well as machine …

[HTML][HTML] Pericytes in the tumor microenvironment

Z Jiang, J Zhou, L Li, S Liao, J He, S Zhou, Y Zhou - Cancer letters, 2023 - Elsevier
Pericytes are a type of mural cell located between the endothelial cells of capillaries and the
basement membrane, which function to regulate the capillary vasomotor and maintain …

A population-level digital histologic biomarker for enhanced prognosis of invasive breast cancer

M Amgad, JM Hodge, MAT Elsebaie, C Bodelon… - Nature Medicine, 2024 - nature.com
Breast cancer is a heterogeneous disease with variable survival outcomes. Pathologists
grade the microscopic appearance of breast tissue using the Nottingham criteria, which are …

Crosstalk between CAFs and tumour cells in head and neck cancer

X Li, C González-Maroto, M Tavassoli - Cell Death Discovery, 2024 - nature.com
Head and neck squamous cell carcinomas (HNSCCs) are amongst the most aggressive,
complex, and heterogeneous malignancies. The standard of care treatments for HNC …

Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy

R Abou Khouzam, B Janji, J Thiery, RF Zaarour… - Seminars in Cancer …, 2023 - Elsevier
In cancer patients, immune cells are often functionally compromised due to the
immunosuppressive features of the tumor microenvironment (TME) which contribute to the …

Convergent inducers and effectors of T cell paralysis in the tumour microenvironment

D Hanahan, O Michielin, MJ Pittet - Nature Reviews Cancer, 2024 - nature.com
Tumorigenesis embodies the formation of a heterotypic tumour microenvironment (TME)
that, among its many functions, enables the evasion of T cell-mediated immune responses …

Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

S He, X Jia, S Feng, J Hu - Small, 2023 - Wiley Online Library
Canonical phototherapeutics have several limitations, including a lack of tumor selectivity,
nondiscriminatory phototoxicity, and tumor hypoxia aggravation. The tumor …

Hypoxic regulation of extracellular vesicles: Implications for cancer therapy

S Yoo, S Choi, I Kim, IS Kim - Journal of Controlled Release, 2023 - Elsevier
Extracellular vesicles (EVs) play a pivotal role in intercellular communication and have been
implicated in cancer progression. Hypoxia, a pervasive hallmark of cancer, is known to …

CD74 promotes a pro-inflammatory tumor microenvironment by inducing S100A8 and S100A9 secretion in pancreatic cancer

WC Hong, DE Lee, HW Kang, MJ Kim, M Kim… - International Journal of …, 2023 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive form of pancreatic cancer with
a poor prognosis and low survival rates. The prognostic and predictive biomarkers of PDAC …

[HTML][HTML] Collagen code in tumor microenvironment: functions, molecular mechanisms, and therapeutic implications

Q Zhang, ZY An, W Jiang, WL Jin, XY He - Biomedicine & Pharmacotherapy, 2023 - Elsevier
The tumor microenvironment (TME) is crucial in cancer progression, and the extracellular
matrix (ECM) is an important TME component. Collagen is a major ECM component that …