Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal
and haematopoietic cells regulate their function. The steady state HSC niche has been …

Simple Summary B cells are an essential component of the immune system and develop in
the bone marrow microenvironment. B-cell development is tightly regulated by the stromal …

Adult mammalian hematopoietic stem cells (HSCs) reside in the bone marrow (BM) but can
be mobilized into blood for use in transplantation. HSCs interact with BM niche cells that …

The bone marrow (BM) exists heterogeneously as hematopoietic/red or adipocytic/yellow
marrow depending on skeletal location, age, and physiological condition. Mouse models …

The hematopoietic stem cell (HSC) niche is a specialized microenvironment, where a
complex and dynamic network of interactions across multiple cell types regulates HSC …

The spatial anatomy of hematopoiesis in the bone marrow (BM) has been extensively
studied in mice and other preclinical models, but technical challenges have precluded a …

A major limitation preventing in vivo modulation of hematopoietic stem cells (HSCs) is the
incomplete understanding of the cellular and molecular support of the microenvironment in …

Hematopoietic stem cells (HSCs) are the cornerstone of the hematopoietic system. HSCs
sustain the continuous generation of mature blood derivatives while self‐renewing to …

Hematopoiesis is hosted, supported and regulated by a special bone marrow (BM)
microenvironment known as “niche.” BM niches have been classified based on micro …

This book summarizes the global progress in medical and scientific research toward
converting traditionally chronic autoimmune diseases into a drug-free reversible illness …