Knowledge of protein structure is paramount to the understanding of biological function,
developing new therapeutics, and making detailed mechanistic hypotheses. Therefore …

Recent advances in cryo-electron microscopy and single-particle reconstruction (collectively
referred to as 'cryoEM') have made it possible to determine the three-dimensional (3D) …

The recent rapid development of single-particle electron cryo-microscopy (cryo-EM) now
allows structures to be solved by this method at resolutions close to 3 Å. Here, a number of …

This Meeting Review describes the proceedings and conclusions from the inaugural
meeting of the Electron Microscopy Validation Task Force organized by the Unified Data …

Cryo-electron microscopy reconstruction methods are uniquely able to reveal structures of
many important macromolecules and macromolecular complexes. EMDataBank. org, a joint …

We describe a method based on Rosetta structure refinement for generating high-resolution,
all-atom protein models from electron cryomicroscopy density maps. A local measure of the …

Atomic-resolution structure determination is crucial for understanding protein function. Cryo-
EM and NMR spectroscopy both provide structural information, but currently cryo-EM does …

Venezuelan equine encephalitis virus (VEEV), a member of the membrane‐containing
Alphavirus genus, is a human and equine pathogen, and has been developed as a …

With fast progresses in instrumentation, image processing algorithms, and computational
resources, single particle electron cryo-microscopy (cryo-EM) 3-D reconstruction of …

A half-century after the determination of the first three-dimensional crystal structure of a
protein, more than 40,000 structures ranging from single polypeptides to large assemblies …