Identifying biomarkers for major depression is of high importance for improving diagnosis
and treatment of this common and debilitating neuropsychiatric disorder, as the field seeks …

Background The causes of major depressive disorder (MDD), as one of the most common
psychiatric disorders, still remain unclear. Neuroimaging has substantially contributed to …

Background Multiple neuropsychiatric disorders, eg, depression, are linked to imbalances in
excitatory and inhibitory neurotransmission and prefrontal cortical dysfunction, and are …

A single, low dose of ketamine evokes antidepressant actions in depressed patients and in
patients with treatment-resistant depression (TRD). Unlike classic antidepressants, which …

Abnormal activity in the medial prefrontal cortex (mPFC) is consistently observed in
neuropsychiatric disorders, but the mechanisms involved remain unclear. Chronic aberrant …

Over the last two decades, the discovery of ketamine's antidepressant properties has
galvanized research into the neurobiology of treatment-resistant depression. Nevertheless …

Emerging evidence suggests that there is a reduction in overall cortical excitatory to
inhibitory balance in major depressive disorder (MDD), which afflicts∼ 14%-20% of …

Rhythmic neuronal activity provides a frame for information coding by co-active cell
assemblies. Abnormal brain rhythms are considered as potential pathophysiological …

Background Early and accurate diagnosis of bipolar and major depressive disorders is
important in clinical practice. However, no diagnostic biomarkers can discriminate bipolar …

Background It is difficult to distinguish bipolar disorder (BD) from major depressive disorder
(MDD), especially with the initial depressive episode. In this study, we compared neural …