Chimeric antigen receptor T‐cell therapy in multiple myeloma: a comprehensive review of current data and implications for clinical practice

RH Parikh, S Lonial - CA: A Cancer Journal for Clinicians, 2023 - Wiley Online Library
Multiple myeloma (MM) is a hematologic malignancy defined by the clonal proliferation of
transformed plasma cells. Despite tremendous advances in the treatment paradigm of MM, a …

A critical analysis of the use of cilgavimab plus tixagevimab monoclonal antibody cocktail (Evusheld™) for COVID-19 prophylaxis and treatment

D Focosi, A Casadevall - Viruses, 2022 - mdpi.com
Evusheld®(tixagevimab+ cilgavimab; AZD7442) was the first anti-Spike monoclonal
antibody (mAb) cocktail designed not only for treatment but also with pre-exposure …

[HTML][HTML] Longitudinal analysis of serum neutralization of SARS-CoV-2 Omicron BA. 2, BA. 4, and BA. 5 in patients receiving monoclonal antibodies

T Bruel, K Stéfic, Y Nguyen, D Toniutti, I Staropoli… - Cell Reports …, 2022 - cell.com
The emergence of Omicron sublineages impacts the therapeutic efficacy of anti-severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) monoclonal antibodies (mAbs) …

Infectious complications, immune reconstitution, and infection prophylaxis after CD19 chimeric antigen receptor T-cell therapy

K Wudhikarn, MA Perales - Bone marrow transplantation, 2022 - nature.com
CD19-targeted chimeric antigen receptor (CAR) T-cell becomes a breakthrough therapy
providing excellent remission rates and durable disease control for patients with …

Association between AZD7442 (Tixagevimab-Cilgavimab) administration and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

J Kertes, S Shapiro Ben David… - Clinical Infectious …, 2023 - academic.oup.com
Background Intramuscular AZD7442 (tixagevimab–cilgavimab [Evusheld; AstraZeneca]) has
been found effective among immunocompromised individuals (ICIs) in reducing SARS-CoV …

Potent high-avidity neutralizing antibodies and T cell responses after COVID-19 vaccination in individuals with B cell lymphoma and multiple myeloma

A Keppler-Hafkemeyer, C Greil, PR Wratil… - Nature Cancer, 2023 - nature.com
Individuals with hematologic malignancies are at increased risk for severe coronavirus
disease 2019 (COVID-19), yet profound analyses of COVID-19 vaccine-induced immunity …

Efficacy and safety of tixagevimab‐cilgavimab as pre‐exposure prophylaxis for COVID‐19: a systematic review and meta‐analysis

AY Soeroto, TA Yanto, A Kurniawan… - Reviews in Medical …, 2023 - Wiley Online Library
Some proportions of populations, such as immunocompromised patients and organ
transplant recipients might have inadequate immune responses to the vaccine for …

Systematic review and meta‐analysis of the clinical effectiveness of tixagevimab/cilgavimab for prophylaxis of COVID‐19 in immunocompromised patients

R Suribhatla, T Starkey, MC Ionescu… - British Journal of …, 2023 - Wiley Online Library
Immunocompromised patients, such as those with a haematological malignancy, are at
higher risk of SARS‐CoV‐2 infection, severe outcomes and mortality. Tixagevimab …

Tixagevimab/cilgavimab in SARS-CoV-2 prophylaxis and therapy: A comprehensive review of clinical experience

K Akinosoglou, EA Rigopoulos, G Kaiafa, S Daios… - Viruses, 2022 - mdpi.com
Effective treatments and vaccines against COVID-19 used in clinical practice have made a
positive impact on controlling the spread of the pandemic, where they are available …

Pre-exposure prophylaxis with tixagevimab/cilgavimab (AZD7442) prevents severe SARS-CoV-2 infection in recipients of allogeneic hematopoietic stem cell …

L Jondreville, M D'Aveni, H Labussière-Wallet… - Journal of Hematology & …, 2022 - Springer
Since the emergence of the Omicron variant of SARS-CoV-2, though considered less
virulent, hospitalization and death rates among immunocompromised patients remain high …