Covalent DNA–protein crosslinks (DPCs) are pervasive DNA lesions that interfere with
essential chromatin processes such as transcription or replication. This review strives to …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

To maintain genome function and stability, DNA sequence and its organization into
chromatin must be duplicated during cell division. Understanding how entire chromosomes …

During the past 6 years, focused virus hunting has led to the discovery of nine new human
polyomaviruses, including Merkel cell polyomavirus, which has been linked to Merkel cell …

Zoonotic poxviruses such as mpox virus (MPXV) continue to threaten public health safety
since the eradication of smallpox. Vaccinia virus (VACV), the prototypic poxvirus used as the …

Magnesium is essential to the proper functioning of numerous cellular processes.
Magnesium ion (Mg 2+) deficits, as reflected in hypomagnesemia, can cause neuromuscular …

Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …

Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and
tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the …

Mammalian cells have evolved mechanisms to silence foreign DNA introduced by viruses or
by transfection. Upon herpesviral infection of cells, the viral genome is chromatinized in an …

Classical 'one-gene/one-disease'models cannot fully reconcile with the increasingly
appreciated prevalence of complicated genotype-to-phenotype associations in human …