The multiple roles of interferon regulatory factor family in health and disease
L Wang, Y Zhu, N Zhang, Y Xian, Y Tang, J Ye… - … and Targeted Therapy, 2024 - nature.com
Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …
influence the immune system, impacting both physiological and pathological processes …
Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure
Summary Rewiring exhausted CD8+ T (Tex) cells toward functional states remains a
therapeutic challenge. Tex cells are epigenetically programmed by the transcription factor …
therapeutic challenge. Tex cells are epigenetically programmed by the transcription factor …
Efficient engineering of human and mouse primary cells using peptide-assisted genome editing
Simple, efficient and well-tolerated delivery of CRISPR genome editing systems into primary
cells remains a major challenge. Here we describe an engineered Peptide-Assisted …
cells remains a major challenge. Here we describe an engineered Peptide-Assisted …
[HTML][HTML] The phenotypic landscape of essential human genes
Understanding the basis for cellular growth, proliferation, and function requires determining
the roles of essential genes in diverse cellular processes, including visualizing their …
the roles of essential genes in diverse cellular processes, including visualizing their …
Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies
L Nicosia, GJ Spencer, N Brooks, FMR Amaral… - Cancer Cell, 2023 - cell.com
CCS1477 (inobrodib) is a potent, selective EP300/CBP bromodomain inhibitor which
induces cell-cycle arrest and differentiation in hematologic malignancy model systems. In …
induces cell-cycle arrest and differentiation in hematologic malignancy model systems. In …
Pharmacological restriction of genomic binding sites redirects PU. 1 pioneer transcription factor activity
Transcription factor (TF) DNA-binding dynamics govern cell fate and identity. However, our
ability to pharmacologically control TF localization is limited. Here we leverage chemically …
ability to pharmacologically control TF localization is limited. Here we leverage chemically …
[HTML][HTML] Short circuit: Transcription factor addiction as a growing vulnerability in cancer
Core regulatory circuitry refers to the network of lineage-specific transcription factors
regulating expression of both their own coding genes, and that of other transcription factors …
regulating expression of both their own coding genes, and that of other transcription factors …
ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells
27-Hydroxycholesterol (27-HC) is the most abundant oxysterol that increases the risk of
breast cancer progression. However, little is known about epigenetic regulation of 27-HC …
breast cancer progression. However, little is known about epigenetic regulation of 27-HC …
A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia
Acute myeloid leukemia with KMT2A (MLL) rearrangements is characterized by specific
patterns of gene expression and enhancer architecture, implying unique core transcriptional …
patterns of gene expression and enhancer architecture, implying unique core transcriptional …
Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state
JC Beltra, MS Abdel-Hakeem, S Manne, Z Zhang… - BioRxiv, 2022 - biorxiv.org
Rewiring exhausted CD8 T cells (TEX) towards more functional states is a major goal of
cancer immunotherapy but has proven challenging due to the epigenetic stability of TEX …
cancer immunotherapy but has proven challenging due to the epigenetic stability of TEX …