The tyrosinase enzyme, which is widely found in microorganisms, animals and plants, has a
significant position in melanogenesis, plays an important role in undesirable browning of …

Tyrosinase is a copper-containing oxidation enzyme, which is responsible for the production
of melanin. This enzyme is widely distributed in microorganisms, animals and plants, and …

Abstract A series of 1, 2, 4-triazole hydrazones (1–16) were synthesized, and their inhibitory
activities and mechanisms on tyrosinase were investigated by ultraviolet spectrophotometry …

A class of new kojic acid hybrids (7a-7o) bearing a 1, 2, 4-triazine moiety were prepared,
and their inhibitory activities and mechanism on tyrosinase were investigated. All derivatives …

As part of our effort to develop potential tyrosinase inhibitors, we have conjugated the well-
known tyrosinase inhibitor kojic acid (KA) with several phenolic natural products such as …

Tyrosinase plays an important role in melanin biosynthesis and enzymatic browning of fresh-
cut fruit and vegetables. To discover potent tyrosinase inhibitors and antibrowning agents, a …

Two novel chitosan oligosaccharide (COS)-hydroxypyridone (HPO) conjugates were
prepared by reacting chitosan oligosaccharide with 2-chloromethyl-5-hydroxypyridone …

Kojic acid-aromatic aldehydes 6a-6m were synthesized and screened for their anti-
tyrosinase activities. These compounds showed potently anti-tyrosinase activity with IC 50 …

Tyrosinase is a copper-containing enzyme which is widely distributed in nature (eg, bacteria,
mammals, fungi) and involved in two consecutive steps of melanin biosynthesis. In humans …

Tyrosinase is involved in the synthesis of neuromelanin in the substantia nigra, which is
closely correlated with the pathogenesis of Parkinson's disease. Herein, we identified …